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Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t6A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.
Gene Name: | O-sialoglycoprotein endopeptidase |
Synonyms: | OSGEP, GCPL1, HOSGEP, OSGEP1, KAE1, PRSMG1 |
Target Sequences: | NM_017807 NP_060277.1 Q9NPF4 |
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