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OPN4 / Melanopsin

opsin 4

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene Name: opsin 4
Family/Subfamily: GPCR , Opsin
Synonyms: OPN4, Opsin 4 (melanopsin), Melanopsin, MOP, Opsin 4, Opsin-4
Target Sequences: AF147788 AAF24978.1 Q9UHM6

Publications (1)

1
Enhancing therapeutic efficacy of human adipose-derived stem cells by modulating photoreceptor expression for advanced wound healing. Sang Ho Lee, Yu-Jin Kim, Yeong Hwan Kim, Han Young Kim, Suk Ho Bhang. Stem cell research & therapy. 2022 May;13:215. [Full Text Article] [PubMed:35619187] [PMC:PMC9137210] Related Antibodies: LS-C384509.

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OPN4 / Melanopsin (4)
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OPN4 / Melanopsin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
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53.6 kDa
20 µg/$215
OPN4 / Melanopsin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.5 kDa
20 µg/$215
OPN4 / Melanopsin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.5 kDa
100 µg/$710
OPN4 / Melanopsin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
53.6 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).