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OPN1MW / GCP is for a light absorbing visual pigment of the opsin gene family. The encoded protein is called green cone photopigment or medium-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. The long-wavelength opsin gene and multiple copies of the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of deutanopic colorblindness.
Gene Name: | opsin 1 (cone pigments), medium-wave-sensitive |
Family/Subfamily: | GPCR , Opsin |
Synonyms: | OPN1MW, CBD, CBBM, COD5, Color blindness, deutan, Cone dystrophy 5 (X-linked), Deutan, Green/red, GCP, Green cone pigment, Green photoreceptor pigment, GOP, Green opsin, OPN1MW1, Photopigment apoprotein, Medium-wave-sensitive opsin 1, Green-sensitive opsin |
Target Sequences: | NM_000513 NP_000504.1 P04001 |
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