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OPN1LW / ROP
opsin 1 (cone pigments), long-wave-sensitive
OPN1LW / ROP is for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness.
| Gene Name: | opsin 1 (cone pigments), long-wave-sensitive |
| Family/Subfamily: | GPCR , Opsin |
| Synonyms: | OPN1LW, CBBM, COD5, Color blindness, protan, Cone dystrophy 5 (X-linked), Red cone opsin, Red cone photoreceptor pigment, Red opsin, ROP, CBP, Long-wave-sensitive opsin 1, RCP, Red-sensitive opsin |
| Target Sequences: | NM_020061 NP_064445.2 P04000 |
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