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OGDH

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

OGDH is one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
Synonyms: OGDH, AKGDH, E1k, Oxoglutarate decarboxylase, OGDC, OGDC-E1
Target Sequences: NM_002541 NP_002532.2 Q02218

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).