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Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L.
|Gene Name:||2'-5'-oligoadenylate synthetase 2, 69/71kDa|
|Synonyms:||OAS2, 2-5A synthase 2, 2-5-oligoadenylate synthase 2, p69OAS / p71OAS, p69 OAS / p71 OAS|
|Target Sequences:||NM_002535 NP_002526.2 P29728|
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