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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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O3FAR1 / GPR120
free fatty acid receptor 4
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
| Gene Name: | free fatty acid receptor 4 |
| Family/Subfamily: | GPCR , Fatty acid |
| Synonyms: | FFAR4, Free fatty acid receptor 4, GT01, GPR129, GPR120, O3FAR1, PGR4, BMIQ10 |
| Target Sequences: | NM_181745 NP_859529.2 Q5NUL3 |
Publications (6)
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