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NXF3

nuclear RNA export factor 3

NXF3 is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus.

Gene Name: nuclear RNA export factor 3
Synonyms: NXF3, Nuclear RNA export factor 3, TAPL-3, TAP-like protein 3, TAPL3
Target Sequences: NM_022052 NP_071335.1 Q9H4D5

Publications (1)

1
Prognostic significance of nuclear RNA export factor 3 in hepatocellular carcinoma. Jiang JH, Gao Q, Ke AW, Yu Y, Shi GM, Fan J, Zhou J, Huang XW. Oncology letters. 2014 7:641-646. (IHC; Human) [Full Text Article] [PubMed:24520286] [PMC:PMC3919940] Related Antibodies: LS-C31687.

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Proteins (5)
Over-Expression Lysate (2)
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NXF3 (5)
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Human (4)
293T Cells (1)
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HEK 293 Cells (1)
Wheat Germ Extract (2)
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NXF3 Protein - 12.5% SDS-PAGE of human NXF3 stained with Coomassie Blue
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Wheat Germ Extract
GST
84.15 kDa
10 µg/$479; 25 µg/$670
NXF3 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
NXF3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
59.9 kDa
100 µg/$494
NXF3 Protein
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E. coli
His-SUMO
76.1 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
NXF3 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
59.9 kDa
20 µg/$150
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).