NUPR1

nuclear protein, transcriptional regulator, 1

Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 'Lys-16' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

NUPR1 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human NUPR1 Protein (Recombinant GST) (Full Length) - LS-G33172

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

34.76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NUPR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87548

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.7 kDa

Price:

20 µg/$150

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NUPR1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114490

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.7 kDa

Price:

100 µg/$494

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Human NUPR1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70603

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

8.7 kDa

Price:

20 µg/$1,107

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