NUP98

nucleoporin 98kDa

Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.

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Proteins (4)

Type

Recombinant (4)

Target

NUP98 (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (2)

Species

Human (3)

Mouse (1)

Source

E. coli (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NUP98 Protein (Recombinant GST) (Full Length) - LS-G29559

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

92.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NUP98 Protein (Recombinant GST, N-terminus) (aa1-110) - LS-G59458

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NUP98 Protein (Recombinant His-T7) (aa629-894) - LS-G13445

Source:

E. coli

Tag:

His-T7

Molecular Weight:

33.6 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Mouse NUP98 Protein (Recombinant His-T7) (aa568-776) - LS-G13447

Source:

E. coli

Tag:

His-T7

Molecular Weight:

26.8 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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