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Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.
Gene Name: | nudix (nucleoside diphosphate linked moiety X)-type motif 21 |
Synonyms: | NUDT21, CFIM25, CPSF25, CPSF 25 kDa subunit, CPSF5, Nudix motif 21 |
Target Sequences: | NM_007006 NP_008937.1 O43809 |
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