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NUDT16

nudix (nucleoside diphosphate linked moiety X)-type motif 16

RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG). Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA; metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase; hydrolyzes the non-canonical purine nucleotides inosine diphosphate (IDP) and deoxyinosine diphosphate (dITP) as well as guanosine diphosphate (GDP), deoxyguanosine diphosphate (dGDP), xanthine diphosphate (XDP), inosine triphosphate (ITP) and deoxyinosine triphosphate (ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy- and ribose forms. The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP. Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Gene Name: nudix (nucleoside diphosphate linked moiety X)-type motif 16
Synonyms: NUDT16, Nudix motif 16, M7GpppN-mRNA hydrolase, U8 snoRNA-binding protein H29K, U8 snoRNA-decapping enzyme
Target Sequences: NP_083661.2 Q6P3D0

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Antibodies (6)
Primary (6)
NUDT16 (6)
Human (5)
Mouse (4)
Dog (3)
Gibbon (3)
Guinea pig (3)
Rabbit (3)
IHC (1)
WB (6)
ELISA (1)
IF (1)
IP (1)
Peptide-ELISA (1)
rabbit (6)
IgG (2)
polyclonal pc (6)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (3)
aa45-94 (4)
No (6)
NUDT16 Antibody - Western blot analysis of extracts of HeLa cells using NUDT16 antibody. The lane on the left was treated with blocking peptide.
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NUDT16 Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NUDT16 Antibody - Nudt16 antibody Western blot of Small Intestine lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT16 Rabbit anti-Mouse Polyclonal (aa45-94) Antibody
Mouse
WB
Unconjugated
100 µl/$424
NUDT16 Antibody - Nudt16 antibody Western blot of Small Intestine lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT16 Rabbit anti-Mouse Polyclonal (aa45-94) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Human, Gibbon
WB
HRP Conjugated
100 µl/$469
NUDT16 Antibody - Nudt16 antibody Western blot of Small Intestine lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT16 Rabbit anti-Mouse Polyclonal (aa45-94) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Human, Gibbon
WB
Biotin Conjugated
100 µl/$469
NUDT16 Antibody - Nudt16 antibody Western blot of Small Intestine lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NUDT16 Rabbit anti-Mouse Polyclonal (aa45-94) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Human, Gibbon
WB
FITC Conjugated
100 µl/$469
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NUDT16 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$351
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).