NUB1

negative regulator of ubiquitin-like proteins 1

NUB1 is a protein that functions as a negative regulator of NEDD8, a ubiquitin-like protein that conjugates with cullin family members in order to regulate vital biological events. The protein encoded by this gene regulates the NEDD8 conjugation system post-transcriptionally by recruiting NEDD8 and its conjugates to the proteasome for degradation. This protein interacts with the product of the AIPL1 gene, which is associated with Leber congenital amaurosis, an inherited retinopathy, and mutations in that gene can abolish interaction with this protein, which may contribute to the pathogenesis. This protein is also known to accumulate in Lewy bodies in Parkinson's disease and dementia with Lewy bodies, and in glial cytoplasmic inclusions in multiple system atrophy, with this abnormal accumulation being specific to alpha-synucleinopathy lesions. Alternative splicing of this gene results in multiple transcript variants.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

NUB1 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NUB1 Protein (Recombinant GST, N-terminus) (aa503-601) - LS-G62514

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NUB1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69312

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.9 kDa

Price:

20 µg/$1,107

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NUB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G112849

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.9 kDa

Price:

100 µg/$494

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Human NUB1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G84332

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.9 kDa

Price:

20 µg/$150

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Human NUB1 Protein (Recombinant GST) (Full Length) - LS-G33866

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

95.5 kDa

Price:

10 µg/$479; 25 µg/$670

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