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NTRK1 / TrkA

neurotrophic tyrosine kinase, receptor, type 1

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Gene Name: neurotrophic tyrosine kinase, receptor, type 1
Family/Subfamily: Protein Kinase , Trk/Ror
Synonyms: NTRK1, Oncogene TRK, TrkA/NGF receptor, Tropomyosin-related kinase A, TRK, TRK1, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, MTC, p140-TrkA, Trk-A, TRKA
Target Sequences: NM_002529 NP_002520.2 P04629

Publications (1)

1
Ultra-purified alginate gel implantation decreases inflammatory cytokine levels, prevents intervertebral disc degeneration, and reduces acute pain after discectomy. Katsuro Ura, Katsuhisa Yamada, Takeru Tsujimoto, Daisuke Ukeba, Norimasa Iwasaki, Hideki Sudo. Scientific reports. 2021 January;11:638. [Full Text Article] [PubMed:33436742] [PMC:PMC7804289]

☰ Filters
Antibodies (119)
Proteins (16)
ELISA Kits (14)
Cell-Based (1)
Cell-Based Phosphorylation (2)
Custom (3)
Over-Expression Lysate (6)
Primary (119)
Recombinant (10)
Sandwich (8)
NTRK1 / TrkA (149)
Human (109)
Mouse (68)
Rat (55)
Chicken (2)
Dog (2)
IHC (45)
IHC-P (13)
WB (84)
Flo (14)
Block (2)
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ELISA (59)
ICC (8)
IF (13)
IP (8)
Peptide-ELISA (12)
SPR (2)
rabbit (103)
mouse (15)
sheep (1)
IgG (78)
IgG,k (1)
IgG1 (5)
IgG1,k (8)
monoclonal mc (14)
polyclonal pc (103)
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02 (1)
185CT47.6.1 (6)
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Unconjugated (83)
pTyr791 (9)
aa654-683 (7)
aa769-796 (7)
pTyr676 (5)
Extracellular Domain (4)
Internal (3)
pTyr496 (3)
440-520 aa (2)
640-720 aa (2)
720-800 aa (2)
TrkA (2)
aa440-796 (2)
aa71-90 (2)
pTyr701 (2)
pTyr757 (2)
620-700 aa (1)
700-780 aa (1)
Ab-701 (1)
Ab-791 (1)
Ala785 (1)
Amino Acid: 33-423 (1)
C-Terminus (1)
Cytoplasmic Domain (1)
Tyr496 (1)
aa447-496 (1)
aa471-520 (1)
aa481-515 (1)
aa631-680 (1)
aa747-796 (1)
p496 (1)
pTyr680 (1)
pTyr680+Tyr681 (1)
pTyr680,pTyr681 (1)
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pTyr680/Tyr681 (1)
No (149)
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Biologically active (1)
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NTRK1 / TrkA Rabbit anti-Rat Polyclonal (Extracellular Domain) Antibody
Mouse, Rat, Human
ICC, IP, WB
Unconjugated
200 µg/$984
NTRK1 / TrkA ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
NTRK1 / TrkA Antibody - Confocal immunofluorescence of PC-12 cells using TrkA mouse monoclonal antibody (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.
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NTRK1 / TrkA Mouse anti-Human Monoclonal (6B2) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µl/$435
NTRK1 / TrkA Antibody - IHC of paraffin-embedded Carcinoma of Human pancreas tissue using anti-NTRK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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NTRK1 / TrkA Mouse anti-Human Monoclonal (aa440-796) (OTI5B6) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
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HEK 293 Cells
None
Biologically active
Less than 0.2 EU/µg protein (determined by LAL method).
65~85 kDa (SDS-PAGE)
50 µg/$342; 10 µg/$253; 1 mg/$2,449
NTRK1 / TrkA Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (Internal) (Magnetic beads) Antibody
Human
IP
Magnetic beads Conjugated
100 µg/$399
NTRK1 / TrkA Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (Internal) (Sepharose) Antibody
Human
IP
Sepharose Conjugated
100 µg/$399
NTRK1 / TrkA Antibody - Confocal immunofluorescence of TrkA Antibody with MDA-MB231 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
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NTRK1 / TrkA Rabbit anti-Human Polyclonal Antibody
Mouse, Human
Flo, IF, WB
Unconjugated
400 µl/$393
NTRK1 / TrkA Antibody - Western blot of anti-TRKA Antibody antibody in mouse liver tissue lysates (35 ug/lane). TRKA(arrow) was detected using the purified polyclonal antibody.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (aa654-683) Antibody
Mouse, Human
Flo, WB
Unconjugated
400 µl/$393
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NTRK1 / TrkA Rabbit anti-Rat Polyclonal (Extracellular Domain) Antibody
Mouse, Rat
IHC, WB
Unconjugated
500 µg/$393
NTRK1 / TrkA Antibody - NTRK1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The NTRK1 antibody detected the NTRK1 protein (arrow).
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NTRK1 / TrkA Mouse anti-Mouse Monoclonal Antibody
Mouse
WB
Unconjugated
400 µl/$393
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NTRK1 / TrkA Sheep anti-Rat Polyclonal (Extracellular Domain) Antibody
Rat
IHC, WB
Unconjugated
500 µg/$393
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (aa769-796) (Biotin) Antibody
Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200 µl/$952
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (aa769-796) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (aa769-796) (APC) Antibody
Human
ELISA, Flo, IHC, WB
APC Conjugated
200 µl/$952
NTRK1 / TrkA Antibody - 1:100 staining human heart tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (pTyr680,pTyr681) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NTRK1 / TrkA Antibody - Western blot of Trk A antibody
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (640-720 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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NTRK1 / TrkA Rabbit anti-Mouse Polyclonal (Cytoplasmic Domain) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
500 µg/$393
NTRK1 / TrkA Antibody - Immunohistochemical analysis of TRK A staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (aa654-683) (Biotin) Antibody
Mouse, Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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NTRK1 / TrkA Mouse anti-Mouse Monoclonal (Biotin) (185CT47.6.1) Antibody
Mouse
ELISA, WB
Biotin Conjugated
200 µl/$952
NTRK1 / TrkA Antibody - Dot blot of anti-Phospho-TrkA-Y791 antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (pTyr791) Antibody
Human
DB, WB
Unconjugated
400 µl/$393
NTRK1 / TrkA Antibody - Immunohistochemical analysis of TRK A (pY496) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (pTyr496) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
NTRK1 / TrkA Antibody - Immunohistochemistry image of paraffin-embedded human gastric cancer at a dilution of 1:100
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NTRK1 / TrkA Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
NTRK1 / TrkA Antibody - TrkA-pY791 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.
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NTRK1 / TrkA Rabbit anti-Human Polyclonal (aa769-796) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
Viewing 1-25 of 149 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).