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Unfortunately, the antibody (ID:156248) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



NTRK1 / TrkA

neurotrophic tyrosine kinase, receptor, type 1

Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand, it can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival. Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.Isoform TrkA-III is resistant to NGF, constitutively activates AKT1 and NF-kappa-B and is unable to activate the Ras-MAPK signaling cascade. Antagonizes the anti-proliferative NGF-NTRK1 signaling that promotes neuronal precursors differentiation. Isoform TrkA-III promotes angiogenesis and has oncogenic activity when overexpressed.

Gene Name: neurotrophic tyrosine kinase, receptor, type 1
Family/Subfamily: Protein Kinase , Trk/Ror
Synonyms: NTRK1, Oncogene TRK, TrkA/NGF receptor, Tropomyosin-related kinase A, TRK, TRK1, Tyrosine kinase receptor, Tyrosine kinase receptor A, gp140trk, MTC, p140-TrkA, Trk-A, TRKA
Target Sequences: NM_002529 NP_002520.2 P04629

Filtered By: None
Target
ntrk1-trka (125)
Reactivity
Human (106)
Mouse (62)
Rat (45)
Bovine (1)
Chicken (1)
Dog (3)
Hamster (1)
Horse (1)
Pig (1)
Rabbit (1)
Sheep (1)
Application
IHC (47)
IHC-P (20)
WB (92)
Flo (16)
DB (8)
ELISA (52)
ICC (9)
IF (10)
IP (17)
Peptide-ELISA (13)
Host
rabbit (110)
mouse (14)
sheep (1)
Isotype
IgG (74)
IgG1 (2)
IgG1,k (9)
IgG2a (1)
Clonality
monoclonal mc (14)
polyclonal pc (111)
Clone
185CT47.6.1 (7)
5B6 (1)
6B2 (1)
TrKA (1)
Format
AP Conjugated (7)
APC Conjugated (6)
Azide-free (5)
Biotin Conjugated (7)
FITC Conjugated (9)
HRP Conjugated (8)
Magnetic beads Conjugated (1)
PE Conjugated (7)
Sepharose Conjugated (1)
Unconjugated (79)
Epitope
pTyr791 (12)
aa654-683 (8)
aa769-796 (8)
Extracellular Domain (6)
pTyr676 (5)
pTyr496 (4)
pTyr701 (4)
C-Terminus (3)
Internal (3)
pTyr757 (3)
aa71-90 (2)
pTyr680 (2)
pTyr680/681 (2)
pTyr680/Tyr681 (2)
Ala785 (1)
Cytoplasmic Domain (1)
Glu492 (1)
aa342-361 (1)
aa350-400 (1)
aa440-520 (1)
aa440-796 (1)
aa447-496 (1)
aa471-520 (1)
aa481-515 (1)
aa631-680 (1)
aa640-720 (1)
aa720-800 (1)
aa747-796 (1)
aa789-793 (1)
Publications
No (125)
Showing 1-25 out of 125 results
Anti-NTRK1 / TrkA Antibody IHC-plus™ LS-B2410
Anti-NTRK1 / TRKA antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2410 concentration 5 ug/ml.
Western blot of TRKA / TRK A antibody LS-B2410.

Rabbit Polyclonal to Human NTRK1 / TrkA
Mouse, Rat, Human
IHC IHC-P IP WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Extracellular Domain) LS-C10868

Rabbit Polyclonal (IgG) to Rat NTRK1 / TrkA
Mouse, Rat, Human
ICC IP WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (clone 6B2) LS-C108757
Confocal immunofluorescence of PC-12 cells using TrkA mouse monoclonal antibody (green), showing membrane and cytoplasmic localization. Blue: DRAQ5 fluorescent DNA dye.
Western blot using TrkA mouse monoclonal antibody against extracellular domain of human TrkA(aa33-423).

Mouse Monoclonal [clone 6B2] (IgG1) to Human NTRK1 / TrkA
Human
ELISA IF WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Glu492) LS-C176477
IHC of Trk A (E492) pAb in paraffin-embedded human brain tissue.
Western blot of Trk A (E492) pAb in extracts from Jurkat cells.

Rabbit Polyclonal to Human NTRK1 / TrkA
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Extracellular Domain) LS-C95062

Rabbit Polyclonal (IgG) to Rat NTRK1 / TrkA
Mouse, Rat
IHC WB
Unconjugated
Anti-NTRK1 / TrkA Antibody LS-C163040
NTRK1 Antibody western blot of mouse brain tissue lysates (35 ug/lane). The NTRK1 antibody detected the NTRK1 protein (arrow).

Mouse Monoclonal (IgG1,k) to Mouse NTRK1 / TrkA
Mouse
WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Extracellular Domain) LS-C94981

Sheep Polyclonal (IgG) to Rat NTRK1 / TrkA
Rat
IHC WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Internal, Magnetic beads) LS-C172119
 This image was taken for the unconjugated form of this product. Other forms have not been tested.

Rabbit Polyclonal to Human NTRK1 / TrkA
Human
IP
Magnetic beads Conjugated
Anti-NTRK1 / TrkA Antibody (aa769-796, Biotin) LS-C206942

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Human
ELISA Flo IHC WB
Biotin Conjugated
Anti-NTRK1 / TrkA Antibody (aa769-796, Azide-free, HRP) LS-C209171

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Human
ELISA Flo IHC WB
HRP Conjugated, Azide-free
Anti-NTRK1 / TrkA Antibody (aa769-796, AP) LS-C206940

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Human
ELISA Flo IHC WB
AP Conjugated
Anti-NTRK1 / TrkA Antibody (aa769-796, APC) LS-C206941

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Human
ELISA Flo IHC WB
APC Conjugated
Anti-NTRK1 / TrkA Antibody (aa769-796, PE) LS-C206943

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Human
ELISA Flo IHC WB
PE Conjugated
Anti-NTRK1 / TrkA Antibody (aa640-720) LS-C386514
Western blot of Trk A antibody

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Mouse, Rat, Human
ELISA IHC WB
Unconjugated
Anti-NTRK1 / TrkA Antibody IHC-plus™ LS-B10664
Anti-NTRK1 / TRKA antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10664 dilution 1:100.
NTRK1 western blot of mouse brain tissue lysates (35 ug/lane). The NTRK1 antibody detected the NTRK1 protein (arrow). (1:4000)

Mouse Monoclonal (IgG1,k) to Human NTRK1 / TrkA
Mouse, Human
IHC IHC-P WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Cytoplasmic Domain) LS-C95172

Rabbit Polyclonal (IgG) to Mouse NTRK1 / TrkA
Mouse, Rat, Human
IHC WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (aa654-683, Biotin) LS-C206937

Rabbit Polyclonal (IgG) to Human NTRK1 / TrkA
Mouse, Human
ELISA Flo WB
Biotin Conjugated
Anti-NTRK1 / TrkA Antibody (aa654-683) LS-C99144
Western blot of anti-TRKA Antibody antibody in mouse liver tissue lysates (35 ug/lane). TRKA(arrow) was detected using the purified polyclonal antibody.
TRKA Antibody flow cytometry of HeLa cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Rabbit Polyclonal to Human NTRK1 / TrkA
Mouse, Human
Flo WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (clone 185CT47.6.1, Biotin) LS-C206342

Mouse Monoclonal [clone 185CT47.6.1] (IgG1,k) to Mouse NTRK1 / TrkA
Mouse
ELISA WB
Biotin Conjugated
Anti-NTRK1 / TrkA Antibody (phospho-Tyr791) LS-C96994
Dot blot of anti-Phospho-TrkA-Y791 antibody on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Rabbit Polyclonal to Human NTRK1 / TrkA
Human
DB WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (Extracellular Domain, clone TrKA) LS-C85470

Mouse Monoclonal [clone TrKA] (IgG2a) to Human NTRK1 / TrkA
Human
WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (phospho-Tyr496) LS-C368452
Immunohistochemical analysis of TRK A (pY496) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Immunofluorescent analysis of TRK A (pY496) staining in NIH3T3 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).

Rabbit Polyclonal to Human NTRK1 / TrkA
Mouse, Rat, Human
ICC IF IHC IHC-P WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (aa769-796) LS-C160220
TrkA-pY791 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human skeletal muscle followed by peroxidase-conjugated secondary antibody and DAB staining.
Western blot of hTrkA-pY791 in HepG2 cell line lysates (35 ug/lane). TRK (arrow) was detected using the purified antibody.

Rabbit Polyclonal to Human NTRK1 / TrkA
Human
Flo IHC IHC-P WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (aa350-400) IHC-plus™ LS-B14120
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot of recombinant human TrkA using 1 ug/ml Rabbit Anti-TrkA Polyclonal Antibody. The signal was developed with IRDye 800 Conjugated Goat Anti-Rabbit IgG. Predicted Size: 120 KD. Observed Size: 120 KD.

Rabbit Polyclonal to Human NTRK1 / TrkA
Human
ELISA IHC IHC-P WB
Unconjugated
Anti-NTRK1 / TrkA Antibody (C-Terminus) IHC-plus™ LS-B14121
Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Brain: Formalin-Fixed, Paraffin-Embedded (FFPE)

Rabbit Polyclonal to Human NTRK1 / TrkA
Human
ELISA IHC IHC-P WB
Unconjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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