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NT5E / eNT / CD73

5'-nucleotidase, ecto (CD73)

NT5E / eNT / CD73 is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name:	5'-nucleotidase, ecto (CD73)
Synonyms:	NT5E, 5-nucleotidase, ecto (CD73), 5'-nucleotidase, 5 nucleotidase (CD73), 5-NT, 5-nucleotidase, 5'-nucleotidase, ecto (CD73), CD73, CD73 antigen, E5NT, Ecto-5-nucleotidase, ENT, EN, NT, Purine 5-Prime-Nucleotidase, NT5, NTE
Target Sequences:	NM_002526 NP_002517.1 P21589

Publications (6)

Hypoxia-inducible factor-1-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor. Hart ML, Grenz A, Gorzolla IC, Schittenhelm J, Dalton JH, Eltzschig HK. Journal of immunology (Baltimore, Md. : 1950). 2011 186:4367-74. [PubMed:21357264] Related Antibodies: LS-B3428.

Simultaneous Overexpression of Functional Human HO-1, E5NT and ENTPD1 Protects Murine Fibroblasts against TNF-a-Induced Injury In Vitro. Cinti A, De Giorgi M, Chisci E, Arena C, Galimberti G, Farina L, Bugarin C, Rivolta I, Gaipa G, Smolenski RT, Cerrito MG, Lavitrano M, Giovannoni R. PloS one. 2015 10:e0141933. (WB; Human) [Full Text Article] [PubMed:26513260] [PMC:PMC4626094]

Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia. Iriyama T, Sun K, Parchim NF, Li J, Zhao C, Song A, Hart LA, Blackwell SC, Sibai BM, Chan LN, Chan TS, Hicks MJ, Blackburn MR, Kellems RE, Xia Y. Circulation. 2015 131:730-41. (IHC; Mouse) [Full Text Article] [PubMed:25538227] [PMC:PMC4751998] Related Antibodies: LS-B2943.

Co-expression of functional human Heme Oxygenase 1, Ecto-5'-Nucleotidase and ecto-nucleoside triphosphate diphosphohydrolase-1 by self-cleaving" 2A peptide system.". Marco De Giorgi, Alessandro Cinti, Iwona Pelikant-Malecka, Elisa Chisci, Marialuisa Lavitrano, Roberto Giovannoni, Ryszard T Smolenski. Plasmid. 2015 May;79:22-9. [Full Text Article] [PubMed:25779031]

CD117 expression in fibroblasts-like stromal cells indicates unfavorable clinical outcomes in ovarian carcinoma patients. Ruixia Huang, Dan Wu, Yuan Yuan, Xiaoran Li, Ruth Holm, Claes G Trope, Jahn M Nesland, Zhenhe Suo. PloS one. 2014 November;9:e112209. [Full Text Article] [PubMed:25380303] [PMC:PMC4224427]

Hyperosmolar expansion medium improves nucleus pulposus cell phenotype. Lisanne T Laagland, Frances C Bach, Laura B Creemers, Christine L Le Maitre, Deepani W Poramba-Liyanage, Marianna A Tryfonidou. JOR spine. 2022 September;5:e1219. [Full Text Article] [PubMed:36203869] [PMC:PMC9520765] Related Antibodies: LS-B8284.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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