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NRSF / REST

RE1-silencing transcription factor

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.

Gene Name: RE1-silencing transcription factor
Synonyms: REST, X2 box repressor, XBR, NRSF
Target Sequences: NM_005612 NP_005603.3 Q13127

Publications (1)

1
The Rare YAP1 Subtype of SCLC Revisited in a Biobank of 39 Circulating Tumor Cell Patient Derived Explant Models: A Brief Report. Sarah M Pearsall, Sam Humphrey, Mitchell Revill, Derrick Morgan, Kristopher K Frese, Melanie Galvin, Alastair Kerr, Mathew Carter, Lynsey Priest, Fiona Blackhall, Kathryn L Simpson, Caroline Dive. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer. 2020 December;15:1836-1843. [Full Text Article] [PubMed:32721553] [PMC:PMC7718082] Related Antibodies: LS-C668231.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).