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Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex By similarity. May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production.
Gene Name: | negative regulator of reactive oxygen species |
Synonyms: | NRROS, ELLP3030, LRRC33, UNQ3030, GARPL1 |
Target Sequences: | NP_940967.1 Q86YC3 |
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