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NRP1 / Neuropilin 1

neuropilin 1

The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity.

Gene Name: neuropilin 1
Synonyms: NRP1, BDCA4, CD304, CD304 antigen, VEGF165 receptor, VEGF165R, Neuropilin 1, Neuropilin-1, Np-1, Npn-1, NRP, NP1, Transmembrane receptor
Target Sequences: NM_003873 NP_003864.4 O14786

Publications (2)

1
A novel function of p38-regulated/activated kinase in endothelial cell migration and tumor angiogenesis. Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu WY, Yu G, Han J, Chen L, Sun P. Molecular and cellular biology. 2012 32:606-18. [PubMed:22124154] [PMC:PMC3266605] Related Antibodies: LS-C163016.
2
Neuropilin-1 cooperates with PD-1 in CD8+ T cells predicting outcomes in melanoma patients treated with anti-PD1. Julien Rossignol, Zakia Belaid, Guillemette Fouquet, Flavia Guillem, Rachel Rignault, Pierre Milpied, Amédée Renand, Tereza Coman, Maud D'Aveni, Michael Dussiot, Elia Colin, Jonathan Levy, Caroline Carvalho, Nicolas Goudin, Nicolas Cagnard, Francine Côté, Joel Babdor, Kanit Bhukhai, Laura Polivka, Amélie E Bigorgne, Héloise Halse, Aurélien Marabelle, Séverine Mouraud, Yves Lepelletier, Thiago T Maciel, Marie-Thérèse Rubio, Delphine Heron, Caroline Robert, Isabelle Girault, Doris Lebeherec, Jean-. iScience. 2022 June;25:104353. [Full Text Article] [PubMed:35874918] [PMC:PMC9301874] Related Antibodies: LS-C177530.

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NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$782
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Microplate
Mouse
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$707
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
3.906 - 250 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NRP1 / Neuropilin 1 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
NRP1 / Neuropilin 1 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
NRP1 / Neuropilin 1 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$929
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
15.625 - 1000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Microplate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich CLIA
96-Well Strip Plate
Human
27.43 - 20000 pg/ml
Chemiluminescent
Plasma, Serum, Tissue Homogenates
1 Plate/$968
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
78.125 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
780 - 50000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$717
NRP1 / Neuropilin 1 ELISA Kit
Select
Custom
96-Well Microplate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$923
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NRP1 / Neuropilin 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NRP1 / Neuropilin 1 ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Human
125 - 8000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
500 Wells/$1,182; 1000 Wells/$1,747
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Rat
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
NRP1 / Neuropilin 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$795
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).