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NRBP1 / NRBP
nuclear receptor binding protein 1
NRBP contains a kinase-homology domain and exhibits an associated kinase activity. In addition, NRBP is a multidomain putative adapter protein containing two putative nuclear receptor binding motifs, a putative binding domain for Src homology-2 domain containing proteins, a bipartite nuclear localization signal, and three sequences rich in glutamic acid, serine, proline, and threonine (PEST) residues. The features of NRBP predict a function as an adapter protein potentially linking signaling pathways involving nuclear receptors and SH2 domain containing proteins. NRBP is a Rac family-interacting protein, forming a complex with activated Rac3. NRBP functions in subcellular trafficking and may be directed to specific subcellular locations through interaction with small GTPases of the Rho family.
| Gene Name: | nuclear receptor binding protein 1 |
| Family/Subfamily: | Protein Kinase , NRBP |
| Synonyms: | NRBP1, MUDPNP, NRBP, BCON3, MADM |
| Target Sequences: | NM_013392 NP_037524.1 Q9UHY1 |
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