NR3C1/Glucocorticoid Receptor

nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

The glucocorticoid receptor (GR), a NR3 Steroid Receptor, mediates the physiological activities of glucocorticoids that modulate development, homeostasis, stress, inflammatory, and immunologic responses. GR has been shown to mediate negative-feedback signals of elevated glucocorticoid levels; impaired GR signaling is a key mechanism in the pathogenesis of stress-related psychiatric disorders such as depression and anxiety. Over ten kindreds and sporadic cases of glucocorticoid resistance have been reported; several of these result from mutations in the GR ligand-binding domain. In addition, tissue-specific changes in glucocorticoid sensitivity have been associated with diseases such as rheumatoid arthritis, systemic lupus erythematosus, a type of bronchial asthma, and possibly AIDS. The human GR has three alternatively spliced isoforms: alpha, beta, and gamma. The alpha and beta isoforms are identical through amino acid 727 but then diverge, with GR alpha containing an additional 50 amino acids and GR beta containing an additional, nonhomologous 15 amino acids. GR alpha is activated by glucocorticoid hormones and can bind to the glucocorticoid response element (GRE). GR beta does not bind glucocorticoid hormones and is transcriptionally inactive; however, GR beta can bind GRE and act as an inhibitor of GR alpha. GR gamma, which contains one additional amino acid (arginine) in the DNA-binding domain based on cDNA translation, has been described by Rivers et al. 1999.

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Products

Proteins (14)

Type

Over-Expression Lysate (6)

Recombinant (8)

Target

NR3C1/Glucocorticoid Receptor (14)

Publications

No (14)

Tag

10His-GST, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His-GST (2)

Myc-DDK (Flag) (6)

TRX-6His, C-terminus (1)

Species

Human (9)

Rat (2)

Source

293T Cells (3)

E. coli (6)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human NR3C1/Glucocorticoid Receptor Protein (Recombinant His) (aa41-184) - LS-G14069

Source:

E. coli

Tag:

His

Molecular Weight:

16.7 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Human NR3C1/Glucocorticoid Receptor Protein (Recombinant GST) (Full Length) - LS-G28719

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

112.1 kDa

Price:

2 µg/$439

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Rat NR3C1/Glucocorticoid Receptor Protein (Recombinant His-GST) (aa564-733) - LS-G24381

Source:

E. coli

Tag:

His-GST

Molecular Weight:

49.7 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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NR3C1/Glucocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121216

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

81.3 kDa

Price:

100 µg/$710

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NR3C1/Glucocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121261

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

100 µg/$494

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NR3C1/Glucocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123343

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

100 µg/$494

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Human NR3C1/Glucocorticoid Receptor Protein (Recombinant TRX-6His, C-terminus) - LS-G137077

Source:

E. coli

Tag:

TRX-6His, C-terminus

Molecular Weight:

47.8 kDa

Price:

20 µg/$364; 1 mg/$1,679; 100 µg/$500

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Human NR3C1/Glucocorticoid Receptor Protein (Recombinant 10His-GST, N-terminus) - LS-G137076

Source:

E. coli

Tag:

10His-GST, N-terminus

Molecular Weight:

59.8 kDa

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human NR3C1/Glucocorticoid Receptor Protein (Recombinant GST, N-terminus) (aa51-140) - LS-G58758

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR3C1/Glucocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76143

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

20 µg/$150

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Human NR3C1/Glucocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76144

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

85.5 kDa

Price:

20 µg/$150

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Human NR3C1/Glucocorticoid Receptor Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76145

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

81.3 kDa

Price:

20 µg/$215

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Human NR3C1/Glucocorticoid Receptor Protein (Recombinant His-GST) (aa532-730) - LS-G14070

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.6 kDa

Price:

10 µg/$281; 50 µg/$440; 100 µg/$702; 200 µg/$877; 1 mg/$1,983; 500 µg/$1,523; 5 mg/$3,067; 2 mg/$2,170

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Rat NR3C1/Glucocorticoid Receptor Protein (Recombinant His) (aa106-211) - LS-G14080

Source:

E. coli

Tag:

His

Molecular Weight:

12.8 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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