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Shirley, MA 01464
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NR2F1 / Coup-TF
nuclear receptor subfamily 2, group F, member 1
COUP-TFI, a NR2 Hepatocyte NF4-Like receptor, has been shown to regulate steroid/thyroid receptor pathways and is essential for neurogenesis, organogenesis, metabolism, homeostasis, and cell fate determination. COUP-TFI mediates the elaboration and patterning of anterior neural gene expression in vertebrates, possibly via effects on the retinoic acid signaling pathways. COUP-TFI has recently been shown to serve as an accessory factor for some ligand-bound nuclear receptors, suggesting that it may modulate, both negatively and positively, a wide range of hormonal responses. In mouse, COUP-TFI is required for proper fetal development, neocortical development, and for postnatal development.
| Gene Name: | nuclear receptor subfamily 2, group F, member 1 |
| Family/Subfamily: | NHR , NR2 Hepatocyte NF4-like |
| Synonyms: | NR2F1, COUP-TF1, COUP-TFI, COUP transcription factor I, ERBAL3, EAR3, TCFCOUP1, TFCOUP1, SVP44, V-erbA-related protein 3, COUP transcription factor 1, Coup-tf, COUP-TF I, Coup-tfa, EAR-3, Svp 46 |
| Target Sequences: | NM_005654 NP_005645.1 P10589 |
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