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Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.
Gene Name: | nuclear receptor subfamily 2, group C, member 1 |
Family/Subfamily: | NHR , NR2 Hepatocyte NF4-like |
Synonyms: | NR2C1, Orphan nuclear receptor TR2, Testicular orphan receptor-2, TR2, TR2 nuclear hormone receptor, TR2-11, Testicular receptor 2 |
Target Sequences: | NM_003297 NP_003288.2 P13056 |
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