NR1I2 / PXR

nuclear receptor subfamily 1, group I, member 2

Pregnane X receptor (PXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to mediate the effects of steroid hormones, including progesterone, glucocorticoid, and pregnenolone, and effects of xenobiotics, through the cytochrome P-450 3A gene family (CYP3A). PXR protects the body from hepatotoxicity of secondary bile acids such as lithocholic acid (LCA) by inducing expression of the hydroxylating cytochrome P450 enzyme CYP3A and promoting detoxification. PXR also has been suggested to regulate drug efflux by activating expression of the MDR1 gene, control the biosynthesis and metabolism of bile acids, and influence the protection of the feto-maternal system from the toxic effects of endogenous steroids and foreign substrates. PXR binds as a heterodimer (with RXR) to the CYP3A promoter region. At least six protein isoforms, produced by alternative splicing, have been reported.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

NR1I2 / PXR (8)

Publications

No (8)

Tag

10His-SUMO, N-terminus + Myc, C-terminus (1)

GST (1)

GST, N-terminus (1)

His-GST (2)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

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Human NR1I2 / PXR Protein (Recombinant GST) (Full Length) - LS-G31369

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

76.2 kDa

Price:

2 µg/$439

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Human NR1I2 / PXR Protein (Recombinant GST, N-terminus) (aa279-378) - LS-G60903

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR1I2 / PXR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72073

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.6 kDa

Price:

20 µg/$1,107

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Human NR1I2 / PXR Protein (Recombinant 10His-SUMO, N-terminus + Myc, C-terminus) (aa1-434) - LS-G56428

Source:

E. coli

Tag:

10His-SUMO, N-terminus + Myc, C-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human NR1I2 / PXR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91346

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.6 kDa

Price:

20 µg/$150

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NR1I2 / PXR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100165

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

49.6 kDa

Price:

100 µg/$494

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Mouse NR1I2 / PXR Protein (Recombinant His-GST) (aa205-390) - LS-G15407

Source:

E. coli

Tag:

His-GST

Molecular Weight:

48.7 kDa

Price:

10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284

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Rat NR1I2 / PXR Protein (Recombinant His-GST) (aa246-431) - LS-G15409

Source:

E. coli

Tag:

His-GST

Molecular Weight:

48.7 kDa

Price:

10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383

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