NR1H4 / FXR

nuclear receptor subfamily 1, group H, member 4

Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol. In the intestine, binding of bile acids to the RXR/FXR complex activates the intestinal bile acid-binding protein (IBABP) and results in increased recycling of bile acids. A pseudogene of FXR, located on chromosome 1 (1p13.1 - 1p13.3), has been identified recently using a comparative genomics approach.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

NR1H4 / FXR (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

His-SUMO (2)

Myc-DDK (Flag) (2)

Species

Human (5)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human NR1H4 / FXR Protein (Recombinant His-SUMO) (aa211-486) - LS-G24613

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

62.2 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human NR1H4 / FXR Protein (Recombinant GST) (Full Length) - LS-G31879

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NR1H4 / FXR Protein (Recombinant His-SUMO) (aa1-476) - LS-G21829

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.8 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Rat NR1H4 / FXR Protein (Recombinant His-GST) (aa375-568) - LS-G24614

Source:

E. coli

Tag:

His-GST

Molecular Weight:

51.3 kDa

Price:

10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252

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Human NR1H4 / FXR Protein (Recombinant GST, N-terminus) (aa363-472) - LS-G61305

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR1H4 / FXR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81747

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.2 kDa

Price:

20 µg/$215

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NR1H4 / FXR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100461

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.2 kDa

Price:

100 µg/$710

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