NR1H4 / FXR

nuclear receptor subfamily 1, group H, member 4

Farnesoid X receptor (FXR), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect bile-acid metabolism in the liver and intestine. FXR binds to target DNA as a heterodimer (with retinoid X receptors) and is activated by bile acids. Binding of bile acids to the RXR/FXR heterodimer in liver represses CYP7A1 expression and bile-acid production, leading to a failure to solubilize and absorb cholesterol. In the intestine, binding of bile acids to the RXR/FXR complex activates the intestinal bile acid-binding protein (IBABP) and results in increased recycling of bile acids. A pseudogene of FXR, located on chromosome 1 (1p13.1 - 1p13.3), has been identified recently using a comparative genomics approach.

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Products

ELISA Kits (9)

Type

Custom (3)

Sandwich (6)

Target

NR1H4 / FXR (9)

Reactivity

Human (3)

Mouse (2)

Rat (3)

Format

96-Well Strip Plate (9)

Publications

No (9)

Sample Type

Cell Lysates (2)

Plasma (2)

Serum (2)

Tissue Homogenates (5)

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Human NR1H4 / FXR (Sandwich ELISA) ELISA Kit - LS-F12188

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse NR1H4 / FXR (Sandwich ELISA) ELISA Kit - LS-F7334

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$854

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Human NR1H4 / FXR (Sandwich ELISA) ELISA Kit - LS-F33672

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Rat NR1H4 / FXR (Custom ELISA) ELISA Kit - LS-F19104

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Bovine NR1H4 / FXR (Custom ELISA) ELISA Kit - LS-F19105

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse NR1H4 / FXR (Custom ELISA) ELISA Kit - LS-F19106

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat NR1H4 / FXR (Sandwich ELISA) ELISA Kit - LS-F55767

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$1,034

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Human NR1H4 / FXR (Sandwich ELISA) ELISA Kit - LS-F5849

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

Select

Rat NR1H4 / FXR (Sandwich ELISA) ELISA Kit - LS-F8975

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

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