NR1H3 / LXR Alpha

nuclear receptor subfamily 1, group H, member 3

Liver X receptor alpha (LXR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the transport and catabolism of cholesterol as well as fatty acid metabolism. LXR alpha also appears to be an important insulin mediating factor in the regulation of lipogenesis. LXR alpha is known to be activated by oxysterols and to regulate a wide range of genes, including members of the ATP-binding cassette (ABC) superfamily of transporter proteins (ABCA1 and ABCG1), surface constituents of plasma lipoproteins like apolipoprotein E, and cholesterol ester transport protein. The induced expression of LXR alpha may be related to foam-cell formation in atherosclerotic lesions. As a result, LXR alpha has been suggested as a potential therapeutic target for treating atherosclerosis. LXR alpha forms a heterodimer with RXR alpha and binds the DR4-type cis-element. Recently LXR alpha has been shown to act as a cAMP-responsive nuclear modulator of renin and c-myc expression, suggesting a possible involvement of LXR alpha in the cardiovascular system and in general gene transcription.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

NR1H3 / LXR Alpha (8)

Publications

No (8)

Tag

GST (1)

His (1)

His-SUMO (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Bovine (1)

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human NR1H3 / LXR Alpha Protein (Recombinant His-SUMO) (aa1-402) - LS-G21671

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

61.7 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Bovine NR1H3 / LXR Alpha Protein (Recombinant His) (aa95-434) - LS-G24615

Source:

E. coli

Tag:

His

Molecular Weight:

41.0 kDa

Price:

10 µg/$289; 50 µg/$492; 100 µg/$785; 200 µg/$982; 1 mg/$2,119; 500 µg/$1,646; 5 mg/$3,431; 2 mg/$2,309

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Mouse NR1H3 / LXR Alpha Protein (Recombinant His-T7) (aa93-432) - LS-G24617

Source:

E. coli

Tag:

His-T7

Molecular Weight:

42.7kd

Price:

10 µg/$287; 50 µg/$480; 100 µg/$767; 200 µg/$957; 1 mg/$2,089; 500 µg/$1,617; 5 mg/$3,347; 2 mg/$2,278

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Human NR1H3 / LXR Alpha Protein (Recombinant His-T7) (aa95-434) - LS-G24616

Source:

E. coli

Tag:

His-T7

Molecular Weight:

41.0 kDa

Price:

10 µg/$280; 50 µg/$437; 100 µg/$700; 200 µg/$872; 1 mg/$1,978; 500 µg/$1,519; 5 mg/$3,053; 2 mg/$2,164

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Human NR1H3 / LXR Alpha Protein (Recombinant GST) (Full Length) - LS-G31926

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

68.31 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NR1H3 / LXR Alpha Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68110

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.2 kDa

Price:

20 µg/$1,107

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Human NR1H3 / LXR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81469

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.2 kDa

Price:

20 µg/$215

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NR1H3 / LXR Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100622

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

50.2 kDa

Price:

100 µg/$710

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