NR1H3 / LXR Alpha

nuclear receptor subfamily 1, group H, member 3

Liver X receptor alpha (LXR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the transport and catabolism of cholesterol as well as fatty acid metabolism. LXR alpha also appears to be an important insulin mediating factor in the regulation of lipogenesis. LXR alpha is known to be activated by oxysterols and to regulate a wide range of genes, including members of the ATP-binding cassette (ABC) superfamily of transporter proteins (ABCA1 and ABCG1), surface constituents of plasma lipoproteins like apolipoprotein E, and cholesterol ester transport protein. The induced expression of LXR alpha may be related to foam-cell formation in atherosclerotic lesions. As a result, LXR alpha has been suggested as a potential therapeutic target for treating atherosclerosis. LXR alpha forms a heterodimer with RXR alpha and binds the DR4-type cis-element. Recently LXR alpha has been shown to act as a cAMP-responsive nuclear modulator of renin and c-myc expression, suggesting a possible involvement of LXR alpha in the cardiovascular system and in general gene transcription.

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Products

ELISA Kits (9)

Type

Custom (3)

Sandwich (6)

Target

NR1H3 / LXR Alpha (9)

Reactivity

Human (4)

Mouse (2)

Rat (2)

Format

96-Well Microplate (1)

96-Well Strip Plate (8)

Publications

No (9)

Sample Type

Cell Lysates (1)

Plasma (4)

Serum (4)

Tissue Homogenates (3)

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Human NR1H3 / LXR Alpha (Sandwich ELISA) ELISA Kit - LS-F12999

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$669

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Human NR1H3 / LXR Alpha (Sandwich ELISA) ELISA Kit - LS-F21177

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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Human NR1H3 / LXR Alpha (Sandwich ELISA) ELISA Kit - LS-F5850

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$730

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Mouse NR1H3 / LXR Alpha (Sandwich ELISA) ELISA Kit - LS-F8165

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$748

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Rat NR1H3 / LXR Alpha (Custom ELISA) ELISA Kit - LS-F19110

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Bovine NR1H3 / LXR Alpha (Custom ELISA) ELISA Kit - LS-F19109

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

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Mouse NR1H3 / LXR Alpha (Custom ELISA) ELISA Kit - LS-F19111

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$669

Select

Human NR1H3 / LXR Alpha (Sandwich ELISA) ELISA Kit - LS-F33642

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

Select

Rat NR1H3 / LXR Alpha (Sandwich ELISA) ELISA Kit - LS-F49288

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.313 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$586

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