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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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NR1H3 / LXR Alpha

nuclear receptor subfamily 1, group H, member 3

Liver X receptor alpha (LXR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the transport and catabolism of cholesterol as well as fatty acid metabolism. LXR alpha also appears to be an important insulin mediating factor in the regulation of lipogenesis. LXR alpha is known to be activated by oxysterols and to regulate a wide range of genes, including members of the ATP-binding cassette (ABC) superfamily of transporter proteins (ABCA1 and ABCG1), surface constituents of plasma lipoproteins like apolipoprotein E, and cholesterol ester transport protein. The induced expression of LXR alpha may be related to foam-cell formation in atherosclerotic lesions. As a result, LXR alpha has been suggested as a potential therapeutic target for treating atherosclerosis. LXR alpha forms a heterodimer with RXR alpha and binds the DR4-type cis-element. Recently LXR alpha has been shown to act as a cAMP-responsive nuclear modulator of renin and c-myc expression, suggesting a possible involvement of LXR alpha in the cardiovascular system and in general gene transcription.

Gene Name: nuclear receptor subfamily 1, group H, member 3
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: NR1H3, Liver X receptor alpha, LXRA, LXR-a, Oxysterols receptor LXR-alpha, LXR alpha, Lxralpha, RLD-1
Target Sequences: NM_005693 NP_005684.2 Q13133

Publications (4)

1
Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. Thomas AC, Eijgelaar WJ, Daemen MJ, Newby AC. PloS one. 2015 10:e0128163. (IHC; Mouse) [Full Text Article] [PubMed:26197235] [PMC:PMC4510387] Related Antibodies: LS-B3526.
2
Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Zinkhan EK, Zalla JM, Carpenter JR, Yu B, Yu X, Chan G, Joss-Moore L, Lane RH. Physiological reports. 2016 4: (WB; Human) [Full Text Article] [PubMed:27401460] [PMC:PMC4945843] Related Antibodies: LS-C172075.
3
Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1. Zinkhan EK, Yu B, Schlegel A. Frontiers in physiology. 2018 May;9:645. (Human) [Full Text Article] [PubMed:29896121] [PMC:PMC5987111] Related Antibodies: LS-C172075.
4
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Schmitt J, Kong B, Stieger B, Tschopp O, Schultze SM, Rau M, Weber A, M[Character fc]llhaupt B, Guo GL, Geier A. Liver international : official journal of the International Association for the Study of the Liver. Apr;35:1133-44. [Full Text Article] [PubMed:25156247] [PMC:PMC4146754] Related Antibodies: LS-B3526.
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Viewing 1-25 of 81 items
NR1H3 / LXR Alpha Antibody - Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $485.00
NR1H3 / LXR Alpha Antibody - Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
NR1H3 / LXR Alpha Antibody - Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
NR1H3 / LXR Alpha Antibody - Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $385.00
NR1H3 / LXR Alpha Antibody - Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $545.00
Select
Mouse Monoclonal (IgG2a) to Human NR1H3 / LXR Alpha
Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100µg   1mg/ml   $815.00
Select
Rabbit Polyclonal to Human NR1H3 / LXR Alpha
Rat, Human
WB
Unconjugated
100µg   1mg/ml   $295.00
Select
Rabbit Polyclonal to Human NR1H3 / LXR Alpha
Rat, Human
IP
Magnetic beads Conjugated
100µg   $325.00
NR1H3 / LXR Alpha Antibody - IF using LXR alpha Antibody
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Goat, Dog, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
ICC, IF, WB
Unconjugated
200µg   1mg/ml   $445.00
NR1H3 / LXR Alpha Antibody - Western blot analysis of extracts of HT29 cell lines, using NR1H3 antibody.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
NR1H3 / LXR Alpha Antibody - Western blot of NR1H3 expression in transfected 293T cell line by NR1H3 monoclonal antibody.
Select
Mouse Monoclonal [clone 3E9] (IgG2a,k) to Human NR1H3 / LXR Alpha
Human
ELISA, WB
Unconjugated
100µg   $365.00
NR1H3 / LXR Alpha Antibody - NR1H3 / LXR Alpha antibody (1ug/ml) staining of Human Spleen lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.
Select
Goat Polyclonal to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Goat, Dog, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
NR1H3 / LXR Alpha Antibody - Western blot testing of NR1H3 antibody and Lane 1: rat liver; 2: MCF-7; 3: HeLa cell lysate
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Hamster, Human
WB
Unconjugated
100µg   $435.00
NR1H3 / LXR Alpha Antibody - Western blot of NR1H3 / LXR Alpha antibody.
Select
Rabbit Polyclonal to Cow NR1H3 / LXR Alpha
Bovine, Cow
WB
Unconjugated
100µl   0.5mg/ml   $275.00; 200µl   0.5mg/ml   $325.00; 500µl   0.5mg/ml   $495.00; 1ml   0.5mg/ml   $635.00
NR1H3 / LXR Alpha Antibody - Immunohistochemical staining of rat liver tissue using a LXR-A polyclonal antibody at a 5 µg/mL dilution.
Select
Rabbit Polyclonal (IgG) to Mouse NR1H3 / LXR Alpha
Mouse
IF, IHC, WB
Unconjugated
100µg   $445.00
NR1H3 / LXR Alpha Antibody - Fluorescent image of U251 cell stained with NR1H3 Antibody. U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with NR1H3 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). NR1H3 immunoreactivity is localized to Nucleus significantly.
Select
Rabbit Polyclonal to Human NR1H3 / LXR Alpha
Human
Flo, IF, WB
Unconjugated
400µl   $325.00
NR1H3 / LXR Alpha Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI1A5] (IgG2a) to Human NR1H3 / LXR Alpha
Human
IHC, WB
Unconjugated
100µl   1mg/ml   $345.00
NR1H3 / LXR Alpha Antibody - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Select
Mouse Monoclonal [clone OTI1A5] (IgG2a) to Human NR1H3 / LXR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Mouse Monoclonal (IgG2a) to Human NR1H3 / LXR Alpha
Human
ELISA, IF, WB
Unconjugated
100µg   $355.00
NR1H3 / LXR Alpha Antibody - 1:100 staining mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
PE Conjugated
200µl   $740.00

Viewing 1-25 of 81 items


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).