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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NR1H3 / LXR Alpha

nuclear receptor subfamily 1, group H, member 3

Liver X receptor alpha (LXR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the transport and catabolism of cholesterol as well as fatty acid metabolism. LXR alpha also appears to be an important insulin mediating factor in the regulation of lipogenesis. LXR alpha is known to be activated by oxysterols and to regulate a wide range of genes, including members of the ATP-binding cassette (ABC) superfamily of transporter proteins (ABCA1 and ABCG1), surface constituents of plasma lipoproteins like apolipoprotein E, and cholesterol ester transport protein. The induced expression of LXR alpha may be related to foam-cell formation in atherosclerotic lesions. As a result, LXR alpha has been suggested as a potential therapeutic target for treating atherosclerosis. LXR alpha forms a heterodimer with RXR alpha and binds the DR4-type cis-element. Recently LXR alpha has been shown to act as a cAMP-responsive nuclear modulator of renin and c-myc expression, suggesting a possible involvement of LXR alpha in the cardiovascular system and in general gene transcription.

Gene Name: nuclear receptor subfamily 1, group H, member 3
Family/Subfamily: NHR , NR1 Thyroid hormone-like
Synonyms: NR1H3, Liver X receptor alpha, LXRA, LXR-a, Oxysterols receptor LXR-alpha, LXR alpha, Lxralpha, RLD-1
Target Sequences: NM_005693 NP_005684.2 Q13133

Publications (4)

1
Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. Thomas AC, Eijgelaar WJ, Daemen MJ, Newby AC. PloS one. 2015 10:e0128163. (IHC; Mouse) [Full Text Article] [PubMed:26197235] [PMC:PMC4510387] Related Antibodies: LS-B3526.
2
Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Zinkhan EK, Zalla JM, Carpenter JR, Yu B, Yu X, Chan G, Joss-Moore L, Lane RH. Physiological reports. 2016 4: (WB; Human) [Full Text Article] [PubMed:27401460] [PMC:PMC4945843] Related Antibodies: LS-C172075.
3
Prenatal Exposure to a Maternal High Fat Diet Increases Hepatic Cholesterol Accumulation in Intrauterine Growth Restricted Rats in Part Through MicroRNA-122 Inhibition of Cyp7a1. Zinkhan EK, Yu B, Schlegel A. Frontiers in physiology. 2018 May;9:645. (Human) [Full Text Article] [PubMed:29896121] [PMC:PMC5987111] Related Antibodies: LS-C172075.
4
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Schmitt J, Kong B, Stieger B, Tschopp O, Schultze SM, Rau M, Weber A, M[Character fc]llhaupt B, Guo GL, Geier A. Liver international : official journal of the International Association for the Study of the Liver. Apr;35:1133-44. [Full Text Article] [PubMed:25156247] [PMC:PMC4146754] Related Antibodies: LS-B3526.
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Filtered by: None
Target
NR1H3 / LXR Alpha (81)
Reactivity
Human (70)
Mouse (32)
Rat (27)
Bat (10)
Bovine (22)
Chicken (5)
Chimpanzee (8)
Cow (8)
Dog (14)
Gibbon (8)
Goat (15)
Guinea pig (8)
Hamster (6)
Horse (10)
Monkey (11)
Orangutan (5)
Pig (20)
Primate (1)
Rabbit (9)
Xenopus (5)
Zebrafish (5)
Application
IHC (14)
IHC-P (5)
WB (76)
Flo (7)
DB (1)
ELISA (19)
ICC (1)
IF (5)
IP (3)
Peptide-ELISA (1)
Host
rabbit (71)
mouse (9)
goat (1)
Isotype
IgG (31)
IgG1 (2)
IgG2a (4)
IgG2a,k (1)
IgG2b (2)
Clonality
monoclonal mc (9)
polyclonal pc (72)
Clone
3E9 (1)
NR1HB11D6 (1)
OTI1A5 (2)
OTI1F5 (2)
Format
AP Conjugated (1)
APC (3)
APC Conjugated (4)
Biotin Conjugated (9)
Carrier-free (2)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
DY488 Conjugated (1)
DY550 Conjugated (1)
DY650 Conjugated (1)
FITC Conjugated (8)
HRP Conjugated (8)
Magnetic beads Conjugated (1)
PE Conjugated (4)
Sepharose Conjugated (1)
Unconjugated (36)
Epitope
aa95-434 (16)
aa226-253 (8)
aa93-432 (8)
C-Terminus (7)
Internal (5)
N-Terminus (4)
aa356-405 (4)
aa69-329 (4)
141-190 aa, Internal (1)
aa164-447 (1)
aa371-385 (1)
aa375-398 (1)
aa384-397 (1)
Publications
No (79)
Yes (2)
Showing 1-25 of 81 results

IHC-plus™ NR1H3 / LXR Alpha Antibody (C-Terminus) LS-B3526
Publications (2)
Publications (2)
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Hamster, Bat, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl 0.5mg/ml  $485.00
Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NR1H3 / LXR Alpha Antibody (C-Terminus, HRP) LS-C437358
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NR1H3 / LXR Alpha Antibody (C-Terminus, Biotin) LS-C437356
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl 1mg/ml  $385.00
Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NR1H3 / LXR Alpha Antibody (C-Terminus, FITC) LS-C437357
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl 1mg/ml  $385.00
Anti-NR1H3 / LXR Alpha antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NR1H3 / LXR Alpha Antibody (aa164-447) LS-C9359
Mouse Monoclonal (IgG2a) to Human NR1H3 / LXR Alpha
Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100µg 1mg/ml  $815.00

NR1H3 / LXR Alpha Antibody (C-Terminus) LS-C172075
Publications (2)
Publications (2)
Rabbit Polyclonal to Human NR1H3 / LXR Alpha
Rat, Human
WB
Unconjugated
100µg 1mg/ml  $295.00

NR1H3 / LXR Alpha Antibody (C-Terminus, Magnetic beads) LS-C172076
Rabbit Polyclonal to Human NR1H3 / LXR Alpha
Rat, Human
IP
Magnetic beads Conjugated
100µg  $325.00

IHC-plus™ NR1H3 / LXR Alpha Antibody LS-B4626
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $545.00
Anti-NR1H3 / LXR Alpha antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of LXR-A in rat liver tissue with LXR-A antibody at 20 ug/ml.

NR1H3 / LXR Alpha Antibody LS-C355579
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Goat, Dog, Rat, Pig, Bat, Gibbon, Orangutan, Chimpanzee, Human, Monkey
ICC, IF, WB
Unconjugated
200µg 1mg/ml  $445.00
IF using LXR alpha Antibody
IF using LXR alpha Antibody

NR1H3 / LXR Alpha Antibody LS-C331934
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Human
IHC, WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Western blot analysis of extracts of HT29 cell lines, using NR1H3 antibody.
Western blot analysis of extract of various cells.

NR1H3 / LXR Alpha Antibody (clone 3E9) LS-C139252
Mouse Monoclonal [clone 3E9] (IgG2a,k) to Human NR1H3 / LXR Alpha
Human
ELISA, WB
Unconjugated
100µg  $365.00
Western blot of NR1H3 expression in transfected 293T cell line by NR1H3 monoclonal antibody.
Detection limit for recombinant GST tagged NR1H3 is 3 ng/ml as a capture antibody.

NR1H3 / LXR Alpha Antibody (aa375-398) LS-C388989
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Hamster, Human
WB
Unconjugated
100µg  $435.00
Western blot testing of NR1H3 antibody and Lane 1: rat liver; 2: MCF-7; 3: HeLa cell lysate

NR1H3 / LXR Alpha Antibody (aa95-434) LS-C374316
Rabbit Polyclonal to Cow NR1H3 / LXR Alpha
Bovine, Cow
WB
Unconjugated
20µl 0.5mg/ml  $215.00; 100µl 0.5mg/ml  $275.00; 200µl 0.5mg/ml  $325.00; 1ml 0.5mg/ml  $635.00
Western blot of NR1H3 / LXR Alpha antibody.

NR1H3 / LXR Alpha Antibody LS-C355582
Rabbit Polyclonal (IgG) to Mouse NR1H3 / LXR Alpha
Mouse
IF, IHC, WB
Unconjugated
100µg  $445.00
Immunohistochemical staining of rat liver tissue using a LXR-A polyclonal antibody at a 5 µg/mL dilution.
Immunofluorescent analysis of rat liver tissue using a LXR-A polyclonal antibody at a 20 µg/mL dilution.

NR1H3 / LXR Alpha Antibody (aa226-253) LS-C162986
Rabbit Polyclonal to Human NR1H3 / LXR Alpha
Human
Flo, IF, WB
Unconjugated
400µl  $325.00
Fluorescent image of U251 cell stained with NR1H3 Antibody. U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with NR1H3 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). NR1H3 immunoreactivity is localized to Nucleus significantly.
Western blot of NR1H3 Antibody in MCF-7 cell line lysates (35 ug/lane). NR1H3 (arrow) was detected using the purified antibody.

NR1H3 / LXR Alpha Antibody (aa69-329, clone OTI1A5) LS-C793891
Mouse Monoclonal [clone OTI1A5] (IgG2a) to Human NR1H3 / LXR Alpha
Human
IHC, WB
Unconjugated
100µl 1mg/ml  $345.00
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)

NR1H3 / LXR Alpha Antibody (aa69-329, clone OTI1A5, Carrier-free) LS-C790486
Mouse Monoclonal [clone OTI1A5] (IgG2a) to Human NR1H3 / LXR Alpha
Human
IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)
Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-NR1H3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.5) at 120°C for 3 min. (1:150)

NR1H3 / LXR Alpha Antibody LS-C806374
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl 1mg/ml  $325.00; 200µl 1mg/ml  $375.00
Immunohistochemistry Image
Western blot Image

NR1H3 / LXR Alpha Antibody LS-C667248
Mouse Monoclonal (IgG2a) to Human NR1H3 / LXR Alpha
Human
ELISA, IF, WB
Unconjugated
100µg  $355.00

NR1H3 / LXR Alpha Antibody (aa226-253) LS-C323433
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
Unconjugated
200µl  $590.00

NR1H3 / LXR Alpha Antibody (aa226-253, Biotin) LS-C520393
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
Biotin Conjugated
200µl  $740.00

NR1H3 / LXR Alpha Antibody (aa226-253, FITC) LS-C223500
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
FITC Conjugated
200µl  $740.00

NR1H3 / LXR Alpha Antibody (aa226-253, AP) LS-C223498
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
AP Conjugated
200µl  $740.00

NR1H3 / LXR Alpha Antibody (aa226-253, APC) LS-C223499
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
APC Conjugated
200µl  $740.00

NR1H3 / LXR Alpha Antibody (aa226-253, PE) LS-C223501
Rabbit Polyclonal (IgG) to Human NR1H3 / LXR Alpha
Human
ELISA, Flo, WB
PE Conjugated
200µl  $740.00
Showing 1-25 of 81 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).