NR1A2 / THRB

thyroid hormone receptor, beta

Thyroid hormone receptor beta (TR beta), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect cholesterol metabolism, hearing, cone development in the eye, and hypothalamopituitary-thyroid axis function. Mice lacking the TR beta locus exhibit elevated thyroid hormone levels, profound hearing loss, impaired weight gain, abnormal bone development, and loss of thyroid-hormone induced activation of cholesterol 7 alpha-hydroxylase (CYP7A). Mutation in the ligand-binding domain of TR beta has been linked to the genetic disorder Resistance to Thyroid Hormone (RTH), and possibly to human cone disorders. Congenital thyroid disorders that impair hearing and result in profound deafness are common in geographic areas with a prevalence of iodine deficiency. Two human TR beta protein isoforms have been identified: TR beta1 (461 aa), TR beta2 (476 aa). Two additional protein isoforms, TR beta3 (390 aa), and a non-DNA binding TR deltabeta3 (288 aa), have been documented in rat.

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ELISA Kits (6)

Type

Custom (4)

DNA Binding (1)

Sandwich (1)

Target

NR1A2 / THRB (6)

Reactivity

Human (2)

Mouse (2)

Rat (3)

Chicken (1)

Format

12 x 8-Well Microstrips (1)

96-Well Strip Plate (5)

Publications

No (6)

Sample Type

Cell Lysates (2)

Nuclear Lysates (1)

Tissue Homogenates (1)

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Rat NR1A2 / THRB (Sandwich ELISA) ELISA Kit - LS-F25245

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$818

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Chicken NR1A2 / THRB (Custom) ELISA Kit - LS-F65312

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Price:

1 Plate/$929

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Human NR1A2 / THRB (Custom) ELISA Kit - LS-F65480

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

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Rat NR1A2 / THRB (Custom) ELISA Kit - LS-F65227

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

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Mouse NR1A2 / THRB (Custom) ELISA Kit - LS-F66010

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Mouse/Human/Rat NR1A2 / THRB (DNA-Binding ELISA) ELISA Kit - LS-F811

Type:

DNA Binding

Format:

12 x 8-Well Microstrips

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Nuclear Lysates

Price:

1 Plate/$694

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