NR0B1 / DAX1

nuclear receptor subfamily 0, group B, member 1

DAX-1 (DSS-AHC critical region on the X chromosome, gene 1) is an orphan NRO Knirps-Like nuclear receptor that is involved in adrenal gland and gonad development. DAX-1 has been shown to negatively regulate transcription of the nuclear receptor steroidogenic factor 1 (SF-1). DAX-1 is also involved in the development and differentiation of anterior pituitary cells and in steroidogenesis. In the nucleus, DAX-1 binds to a retinoic acid-responsive element (RARE) and acts as a dominant-negative regulator of retinoic acid receptor-mediated transcription. DAX-1 gene transcription is regulated by Ad4BP/SF-1 (NR5A1) and is suppressed by androgens and the androgen receptor (AR/NR3C4); AR down-regulated DAX-1 gene transcription is mediated by Ad4BP/SF-1 in the presence of the ligand. Recently it has been shown that DAX-1 is required for testis development (Meeks et al. 2003). Mutations in the human DAX-1 gene lead to X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism. Recently two isoforms of DAX-1 has been identified.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

NR0B1 / DAX1 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (1)

His-T7, N-terminus (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Rat (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (3)

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Human NR0B1 / DAX1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66494

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.5 kDa

Price:

20 µg/$1,107

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NR0B1 / DAX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123173

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.5 kDa

Price:

100 µg/$494

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Human NR0B1 / DAX1 Protein (Recombinant GST, N-terminus) (aa361-470) - LS-G57735

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human NR0B1 / DAX1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77834

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

51.5 kDa

Price:

20 µg/$150

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Mouse NR0B1 / DAX1 Protein (Recombinant His-T7, N-terminus) (Met1-Ala227) - LS-G133498

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

28.2kDa

Price:

10 µg/$279; 50 µg/$432; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Rat NR0B1 / DAX1 Protein (Recombinant His-T7, N-terminus) (Met1-Ala227) - LS-G133581

Source:

E. coli

Tag:

His-T7, N-terminus

Molecular Weight:

28.4kDa

Price:

10 µg/$281; 50 µg/$442; 200 µg/$882; 100 µg/$705; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

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Human NR0B1 / DAX1 Protein (Recombinant GST) (Full Length) - LS-G27398

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

78.1 kDa

Price:

2 µg/$439

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