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Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity.
Gene Name: | natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) |
Synonyms: | NPR3, ANPRC, C5orf23, GUCY2B, NPR-C, NPRC, ANP-C, ANPR-C |
Target Sequences: | NM_000908 NP_000899.1 P17342 |
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