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NPL / C112

N-acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase)

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.

Gene Name: N-acetylneuraminate Pyruvate Lyase (Dihydrodipicolinate Synthase)
Synonyms: NPL, C1orf13, Sialic acid lyase, Sialate-pyruvate lyase, N-acetylneuraminate lyase, NAL, Sialate lyase, Sialic acid aldolase, C112, DHDPS1, NALase, NPL1
Target Sequences: NM_030769 NP_110396.1 Q9BXD5

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Proteins (5)
Over-Expression Lysate (2)
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NPL / C112 (5)
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GST (1)
His (1)
Myc-DDK (Flag) (3)
Human (4)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (1)
NPL / C112 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
NPL / C112 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
NPL / C112 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
NPL / C112 Protein - Purified recombinant protein NPL was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
20 µg/$1,107
NPL / C112 Protein - 12.5% SDS-PAGE of human NPL stained with Coomassie Blue
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Wheat Germ Extract
GST
53.2 kDa
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).