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NPHS1 / Nephrin

nephrosis 1, congenital, Finnish type (nephrin)

NPHS1 / Nephrin is a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.

Gene Name: nephrosis 1, congenital, Finnish type (nephrin)
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: NPHS1, Nephrin, NPHN, CNF
Target Sequences: NM_004646 NP_004637.1 O60500

Publications (5)

1
Intrarenal Toll-like receptor 4 and Toll-like receptor 2 expression correlates with injury in antineutrophil cytoplasmic antibody-associated vasculitis. O'Sullivan KM, Ford SL, Longano A, Kitching AR, Holdsworth SR. American journal of physiology. Renal physiology. 2018 November;315:F1283-F1294. [Full Text Article] [PubMed:29923769] [PMC:PMC6293285]
2
Mechanism of Albuminuria Reduction by Chymase Inhibition in Diabetic Mice. Kentaro Terai, Denan Jin, Kenji Watase, Akihisa Imagawa, Shinji Takai. International journal of molecular sciences. 2020 October;21: [Full Text Article] [PubMed:33050674] [PMC:PMC7589797] Related Antibodies: LS-B1382.
3
Effect of suramin on urinary excretion of diabetes-induced glomerular and tubular injury parameters in rats. K Salaga-Zaleska, P Pikul, E Kreft, S Herman, G Chyla, K Dabkowski, A Kuchta, M Lenartowicz, M Jankowski. Biomedicine & pharmacotherapy = Biomdecine & pharmacothrapie. 2021 July;139:111683. [Full Text Article] [PubMed:34243631]
4
Urinary Nephrin as a Biomarker of Glomerular Maturation and Injury Is Associated with Acute Kidney Injury and Mortality in Critically Ill Neonates. Jiao Chen, Gen Li, Sanfeng Wang, Xiaohan Hu, Yunqing Sun, Xiaomei Dai, Zhenjiang Bai, Jian Pan, Xiaozhong Li, Jian Wang, Yanhong Li. Neonatology. 2019 April;116:58-66. [Full Text Article] [PubMed:30982033]
5
A glomerulus-on-a-chip to recapitulate the human glomerular filtration barrier. Petrosyan A, Cravedi P, Villani V, Angeletti A, Manrique J, Renieri A, De Filippo RE, Perin L, Da Sacco S. Nature communications. 2019 August;10:3656. [Full Text Article] [PubMed:31409793] [PMC:PMC6692336] Related Antibodies: LS-C370063.
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ELISA Kits (22)
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Custom (1)
Development Kit (2)
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Sandwich CLIA (2)
NPHS1 / Nephrin (22)
Human (7)
Mouse (6)
Rat (5)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Product Group
DevKit DuoPlus (2)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (16)
Antibody Pair and Standard (2)
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Yes (2)
Cell Culture Supernatants (6)
Cell Lysates (5)
Citrate Plasma (1)
EDTA Plasma (1)
Heparin Plasma (1)
Plasma (10)
Serum (11)
Tissue Homogenates (8)
Urine (7)
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$771
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Microplate
Mouse
0.16 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
1 Plate/$782
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
1 Plate/$764
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates, Urine
1 Plate/$818
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
NPHS1 / Nephrin ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Chicken
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
1.563 - 100 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
NPHS1 / Nephrin ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
NPHS1 / Nephrin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Mouse
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
NPHS1 / Nephrin ELISA Kit
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Competitive EIA
96-Well Strip Plate
Rat
1 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
NPHS1 / Nephrin ELISA Kit
Select
Sandwich CLIA
96-Well Strip Plate
Mouse
54.87 - 40000 pg/ml
Chemiluminescent
Cell Culture Supernatants, Tissue Homogenates, Urine
1 Plate/$990
NPHS1 / Nephrin ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
NPHS1 / Nephrin ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
500 Wells/$1,254; 1000 Wells/$1,867
NPHS1 / Nephrin ELISA Kit
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Sandwich
Human
156 - 10000 pg/ml
Cell Culture Supernatants, Citrate Plasma, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$1,150
NPHS1 / Nephrin ELISA Kit
Select
Development Kit
Antibody Pair and Standard
Mouse
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
500 Wells/$1,207; 1000 Wells/$1,787
NPHS1 / Nephrin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).