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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NPHP1 / Nephronophthisis

nephronophthisis 1 (juvenile)

NPHP1 / Nephronophthisis is a protein with src homology domain 3 (SH3) patterns. This protein interacts with Crk-associated substrate, and it appears to function in the control of cell division, as well as in cell-cell and cell-matrix adhesion signaling, likely as part of a multifunctional complex localized in actin- and microtubule-based structures. Mutations in this gene cause familial juvenile nephronophthisis type 1, a kidney disorder involving both tubules and glomeruli. Defects in this gene are also associated with Senior-Loken syndrome type 1, also referred to as juvenile nephronophthisis with Leber amaurosis, which is characterized by kidney and eye disease, and with Joubert syndrome type 4, which is characterized by cerebellar ataxia, oculomotor apraxia, psychomotor delay and neonatal breathing abnormalities, sometimes including retinal dystrophy and renal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene Name: nephronophthisis 1 (juvenile)
Synonyms: NPHP1, JBTS4, Nephrocystin 1, Nephronophthisis, SLSN1, Nephrocystin-1, Nephronophthisis 1 (juvenile), NPH1
Target Sequences: NM_000272 NP_000263.2 O15259

Filtered By: None
Target
NPHP1 / Nephronophthisis (13)
Reactivity
Human (12)
Mouse (9)
Rat (8)
Bat (4)
Bovine (4)
Chimpanzee (3)
Dog (4)
Guinea pig (4)
Horse (4)
Monkey (4)
Pig (4)
Rabbit (4)
Xenopus (4)
Application
IHC (6)
IHC-P (4)
WB (13)
ELISA (4)
IF (2)
Host
rabbit (13)
Isotype
IgG (5)
Clonality
polyclonal pc (13)
Format
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
Unconjugated (7)
Epitope
aa467-516 (4)
Internal (1)
aa463-732 (1)
Publications
No (13)
Showing 1-13 of 13 results

NPHP1 / Nephronophthisis Antibody IHC-plus™ LS-B12264
Rabbit Polyclonal (IgG) to Human NPHP1 / Nephronophthisis
Human
ELISA IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (HRP) LS-C318825
Rabbit Polyclonal (IgG) to Human NPHP1 / Nephronophthisis
Human
ELISA IHC IHC-P WB
HRP Conjugated
50µg  $285.00; 100µg  $385.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (Biotin) LS-C317168
Rabbit Polyclonal (IgG) to Human NPHP1 / Nephronophthisis
Human
ELISA IHC IHC-P WB
Biotin Conjugated
50µg  $285.00; 100µg  $385.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (FITC) LS-C317167
Rabbit Polyclonal (IgG) to Human NPHP1 / Nephronophthisis
Human
ELISA IHC IHC-P WB
FITC Conjugated
50µg  $285.00; 100µg  $385.00
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (aa467-516) LS-C111795
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Xenopus, Bat, Rat, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Human, Monkey
WB
Unconjugated
50µg  $365.00
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (aa467-516, HRP) LS-C461107
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100µl 0.65mg/ml  $385.00
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (aa467-516, Biotin) LS-C461105
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100µl 1mg/ml  $385.00
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody (aa467-516, FITC) LS-C461106
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Xenopus, Bat, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100µl 1mg/ml  $385.00
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
NPHP1 antibody Western blot of Fetal Heart lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.

NPHP1 / Nephronophthisis Antibody LS-C412559
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Mouse, Rat, Human
IF IHC WB
Unconjugated
100µl  $385.00

NPHP1 / Nephronophthisis Antibody (aa463-732) LS-C334864
Rabbit Polyclonal (IgG) to Human NPHP1 / Nephronophthisis
Mouse, Rat, Human
IF IHC WB
Unconjugated
50µl  $235.00; 100µl  $315.00; 200µl  $425.00
Immunofluorescence analysis of U2OS cell using NPHP1 antibody. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cells.
Immunofluorescence analysis of U2OS cell using NPHP1 antibody. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cells.

NPHP1 / Nephronophthisis Antibody LS-C26560
Rabbit Polyclonal to Mouse NPHP1 / Nephronophthisis
Mouse
WB
Unconjugated
250µg  $355.00

NPHP1 / Nephronophthisis Antibody LS-C314005
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Mouse, Rat, Human
WB
Unconjugated
100µl  $385.00

NPHP1 / Nephronophthisis Antibody (Internal) LS-C352589
Rabbit Polyclonal to Human NPHP1 / Nephronophthisis
Mouse, Rat, Human
WB
Unconjugated
100µl 1mg/ml  $245.00
Western blot analysis of Nephrocystin 1 expression in HeLa (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
Western blot analysis of Nephrocystin 1 expression in HeLa (A); Raw264.7 (B); H9C2 (C) whole cell lysates.
Showing 1-13 of 13 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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