NPC2

Niemann-Pick disease, type C2

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

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Products

Proteins (9)

Type

Over-Expression Lysate (2)

Recombinant (7)

Target

NPC2 (9)

Publications

No (9)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (3)

His-GST (1)

Myc-DDK (Flag) (2)

Species

Dog (3)

Human (4)

Rat (1)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (1)

Human Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human NPC2 Protein (Recombinant GST) (Full Length) - LS-G32234

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

42.35 kDa

Price:

10 µg/$479; 25 µg/$670

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Human NPC2 Protein (Recombinant GST, N-terminus) (aa52-151) - LS-G61569

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Dog NPC2 Protein (Recombinant His) (aa22-149) - LS-G21708

Source:

E. coli

Tag:

His

Molecular Weight:

18.1 kD

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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Dog NPC2 Protein (Recombinant His) (aa22-149) - LS-G23399

Source:

Yeast

Tag:

His

Molecular Weight:

16 kD

Price:

100 µg/$679; 20 µg/$429; 1 mg/$1,973

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Human NPC2 Protein (Recombinant His-GST) (aa20-151) - LS-G26092

Source:

E. coli

Tag:

His-GST

Molecular Weight:

44.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Rat NPC2 Protein (Recombinant His) (Met1-Gly152) - LS-G98451

Source:

Human Cells

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

15.9 kDa

Price:

100 µg/$843

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Human NPC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G86532

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.57 kDa

Price:

20 µg/$150

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NPC2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100819

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.57 kDa

Price:

100 µg/$494

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Dog NPC2 Protein (Recombinant 6His-SUMO, N-terminus) (aa22-149) - LS-G56743

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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