NPC2

Niemann-Pick disease, type C2

Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Both NPC1 and NPC2 function as the cellular 'tag team duo' (TTD) to catalyze the mobilization of cholesterol within the multivesicular environment of the late endosome (LE) to effect egress through the limiting bilayer of the LE. NPC2 binds unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes and transfers it to the cholesterol-binding pocket of the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket and is exported from the limiting membrane of late endosomes/ lysosomes to the ER and plasma membrane by an unknown mechanism. The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport.

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Products

ELISA Kits (6)

Type

Custom (4)

Sandwich (2)

Target

NPC2 (6)

Reactivity

Human (2)

Mouse (1)

Bovine (1)

Dog (1)

Pig (1)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Human NPC2 (Sandwich ELISA) ELISA Kit - LS-F9488

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$902

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Bovine NPC2 (Custom) ELISA Kit - LS-F66162

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$783

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Dog NPC2 (Custom) ELISA Kit - LS-F65224

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Dog

Price:

1 Plate/$929

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Mouse NPC2 (Custom) ELISA Kit - LS-F66422

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Human NPC2 (Custom) ELISA Kit - LS-F65615

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

Select

Pig NPC2 (Sandwich ELISA) ELISA Kit - LS-F66636

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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