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Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity.
Gene Name: | NADPH oxidase organizer 1 |
Synonyms: | NOXO1, NADPH oxidase organizer 1, Nox-organizing protein 1, p41NOX, p41NOXA, p41NOXC, Regulatory protein P41NOX, Nox organizer 1, p41NOXB, SH3PXD5, SNX28 |
Target Sequences: | NM_144603 NP_751908.1 Q8NFA2 |
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