NOT1 / CNOT1

CCR4-NOT Transcription Complex, Subunit 1

Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE)-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of emryonic stem (ES) cell identity.

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Proteins (1)

Type

Recombinant (1)

Target

NOT1 / CNOT1 (1)

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No (1)

Tag

GST, N-terminus (1)

Species

Human (1)

Source

Wheat Germ Extract (1)

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Human NOT1 / CNOT1 Protein (Recombinant GST, N-terminus) (aa2278-2375) - LS-G61902

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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