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Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.
Gene Name: | nitric oxide synthase trafficking |
Synonyms: | NOSTRIN, BM247 homolog, ENOS traffic inducer, ENOS-trafficking inducer, DaIP2 |
Target Sequences: | NM_001039724 |
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