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NOS2 / iNOS

nitric oxide synthase 2, inducible

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.

Gene Name: nitric oxide synthase 2, inducible
Synonyms: NOS2, Hepatocyte NOS, HEP-NOS, Inducible NOS, NOS, type II, NOS type II, Inducible NO synthase, NOS2A, INOS, NOS
Target Sequences: NM_000625 NP_000616.3 P35228

Publications (8)

1
Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms. Yang A, Herter-Sprie G, Zhang H, Lin EY, Biancur D, Wang X, Deng J, Hai J, Yang S, Wong KK, Kimmelman AC. Cancer discovery. 2018 March;8:276-287. [Full Text Article] [PubMed:29317452] [PMC:PMC5835190]
2
Acquisition of heroin conditioned immunosuppression requires IL-1 signaling in the dorsal hippocampus. Lebonville CL, Jones ME, Hutson LW, Cooper LB, Fuchs RA, Lysle DT. Brain, behavior, and immunity. 2016 August;56:325-34. [Full Text Article] [PubMed:27072068] [PMC:PMC4917416]
3
Interleukin-1 signaling in the basolateral amygdala is necessary for heroin-conditioned immunosuppression. Hutson LW, Lebonville CL, Jones ME, Fuchs RA, Lysle DT. Brain, behavior, and immunity. 2017 May;62:171-179. [Full Text Article] [PubMed:28131792] [PMC:PMC5828772]
4
Testosterone regulates thyroid cancer progression by modifying tumor suppressor genes and tumor immunity. Lisa J Zhang, Yin Xiong, Naris Nilubol, Mei He, Swaroop Bommareddi, Xuguang Zhu, Li Jia, Zhen Xiao, Jeong-Won Park, Xia Xu, Dhaval Patel, Mark C Willingham, Sheue-Yann Cheng, Electron Kebebew. Carcinogenesis. 2015 April;36:420-8. [Full Text Article] [PubMed:25576159] [PMC:PMC4392603] Related Antibodies: LS-C15859.
5
rhBMP2 alone does not induce macrophage polarization towards an increased inflammatory response. Emily L Durham, Rajiv Kishinchand, Zachary J Grey, James J Cray. Molecular immunology. 2020 January;117:94-100. [Full Text Article] [PubMed:31759326] [PMC:PMC6931256]
6
Mystery Solved: Why Smoke Extract Worsens Disease in Smokers with Crohn's Disease and Not Ulcerative Colitis? Gut MAP!. Dania AlQasrawi, Latifa S Abdelli, Saleh A Naser. Microorganisms. 2020 May;8:666. [Full Text Article] [PubMed:32370298] [PMC:PMC7284734]
7
T-cell derived acetylcholine aids host defenses during enteric bacterial infection with Citrobacter rodentium. Valerie T Ramirez, Dayn R Godinez, Ingrid Brust-Mascher, Eric B Nonnecke, Patricia A Castillo, Mariana Barboza Gardner , Diane Tu, Jessica A Sladek, Elaine N Miller, Carlito B Lebrilla, Charles L Bevins, Melanie G Gareau, Colin Reardon. PLoS pathogens. 2019 Apr;15:e1007719. [Full Text Article] [PubMed:30973939] [PMC:PMC6478367] Related Antibodies: LS-B10049.
8
Anti-inflammatory properties of a proprietary bromelain extract (Bromeyal™) after in vitro simulated gastrointestinal digestion. Roberta Bottega, Ilaria Persico, Francesco De Seta, Federico Romano, Giovanni Di Lorenzo. International journal of immunopathology and pharmacology. 2021 August;35:20587384211034686. [Full Text Article] [PubMed:34387509] [PMC:PMC8366142]
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Antibodies (137)
Primary (137)
NOS2 / iNOS (137)
Human (90)
Mouse (55)
Rat (36)
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IHC (28)
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rabbit (120)
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monoclonal mc (17)
polyclonal pc (116)
recombinant monoclonal rmc (4)
400000 (1)
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C-Terminus (5)
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pTyr151 (4)
90-170 aa (2)
aa25-54 (2)
N-Terminus (1)
Val1131 (1)
aa1009-1026 (1)
aa1101-1150 (1)
aa1131-1144 (1)
aa115-304 (1)
aa117-166 (1)
aa830-860 (1)
aa997-1058 (1)
p151 (1)
No (135)
Yes (2)
NOS2 / iNOS Antibody - Immunohistochemical analysis of iNOS staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NOS2 / iNOS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
NOS2 / iNOS Antibody - Western blot of NOS2 / iNOS antibody.
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NOS2 / iNOS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Mammal
ICC, IP, WB
Unconjugated
1 Each/$431
NOS2 / iNOS Antibody - Immunohistochemical analysis of iNOS staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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NOS2 / iNOS Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Bovine, Rat, Human
IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
NOS2 / iNOS Antibody - Western blot of recombinant NOS2 / iNOS.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NOS2 / iNOS Rabbit anti-Human Polyclonal (aa533-696) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
NOS2 / iNOS Antibody - Immunohistochemistry-Paraffin: iNOS Antibody (4E5) - Immunohistochemical analysis of paraffin-embedded breast cancer tissues using iNOS mouse mAb with DAB staining.
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NOS2 / iNOS Mouse anti-Human Monoclonal (4E5) Antibody
Mouse, Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
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NOS2 / iNOS Mouse anti-Human Monoclonal (aa1009-1026) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
1 ml/$688
NOS2 / iNOS Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NOS2 / iNOS Rabbit anti-Human Polyclonal (aa830-860) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
200 µl/$460
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NOS2 / iNOS Mouse anti-Human Monoclonal (aa781-798) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
1 ml/$688
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NOS2 / iNOS Mouse anti-Human Monoclonal (aa25-54) (7C204) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
100 µl/$618
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NOS2 / iNOS Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$832
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NOS2 / iNOS Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat
ICC, IHC, WB
Unconjugated
50 µl/$786
NOS2 / iNOS Antibody - iNOS Antibody in Immunohistochemistry (IHC)
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NOS2 / iNOS Mouse anti-Human Monoclonal (400000) Antibody
Mouse, Human
Flo, ICC, IF, IHC, WB
Unconjugated
100 µg/$503
NOS2 / iNOS Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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NOS2 / iNOS Rabbit anti-Human Polyclonal Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$460
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NOS2 / iNOS Mouse anti-Human Monoclonal (aa985-1002) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
100 µl/$618
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NOS2 / iNOS Mouse anti-Human Monoclonal (aa781-798) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
1 ml/$688
Select
NOS2 / iNOS Mouse anti-Human Monoclonal (aa25-54) Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
1 ml/$688
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NOS2 / iNOS Mouse anti-Human Monoclonal Antibody
Human
ELISA, ICC, IF, WB
Unconjugated
1 ml/$688
NOS2 / iNOS Antibody - Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using iNOS Antibody. The picture on the right is blocked with the synthesized peptide.
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NOS2 / iNOS Rabbit anti-Human Polyclonal (aa1101-1150) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NOS2 / iNOS Antibody - Western blot of NOS2 / iNOS antibody.
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NOS2 / iNOS Rabbit anti-Rat Polyclonal (aa530-693) Antibody
Mouse, Rat
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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NOS2 / iNOS Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µl/$820
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NOS2 / iNOS Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
50 µg/$411
NOS2 / iNOS Antibody - Western blot analysis of lysates from NIH/3T3 cells, using iNOS Antibody. The lane on the right is blocked with the synthesized peptide.
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NOS2 / iNOS Rabbit anti-Human Polyclonal (aa117-166) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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NOS2 / iNOS Rabbit anti-Human Polyclonal (aa108-138) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
NOS2 / iNOS Antibody - 1:200 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NOS2 / iNOS Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NOS2 / iNOS Antibody - IHC of iNOS on an FFPE Liver Tissue
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NOS2 / iNOS Rabbit anti-Human Recombinant Monoclonal (RBT-iNOS) Antibody
Human
IHC-Fr, IHC-P
Unconjugated
0.1 ml/$316
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).