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Nor-1 / NR4A3
nuclear receptor subfamily 4, group A, member 3
Nor-1 / NR4A3 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | nuclear receptor subfamily 4, group A, member 3 |
| Family/Subfamily: | NHR , NR4 Nerve growth factor-like |
| Synonyms: | NR4A3, CHN, MINOR, NOR1, Neuron-derived orphan receptor, Nuclear hormone receptor NOR-1, Nor-1, CSMF, Orphan receptor nor1, TEC receptor |
| Target Sequences: | NM_006981 NP_008912.2 Q92570 |
Publications (1)
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