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NOL3 / ARC

nucleolar protein 3 (apoptosis repressor with CARD domain)

Apoptosis is regulated by death domain (DD) and/or caspase recruitment domain (CARD) containing molecules and a caspase family of proteases. CARD domain containing cell death regulators include RAIDD, Apaf-1, caspase-9, and caspase-2. A novel CARD domain containing protein was recently identified and designated ARC for apoptosis repressor with CARD (1). ARC interacts with caspase-2 and -8 and inhibits enzymatic activity of caspase-8. ARC suppresses apoptosis induced by cell death adapters FADD and TRADD and by cell death receptors Fas, TNFR-1 and DR3. ARC is phosphorylated by casein kinase II (CK2) and phosphorylation is necessary to prevent apoptosis.

Gene Name: nucleolar protein 3 (apoptosis repressor with CARD domain)
Family/Subfamily: Apoptosis , not assigned-Apoptosis
Synonyms: NOL3, Apoptosis repressor with CARD, CARD2, FCM, NOP, Nucleolar protein 3, Nucleolar protein of 30 kDa, MYP, NOP30
Target Sequences: NM_003946 NP_003937.1 O60936

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
NOL3 / ARC (10)
No (10)
GST (1)
GST, N-terminus (2)
His (2)
His-SUMO (1)
Myc-DDK (Flag) (3)
Human (9)
293T Cells (1)
E. coli (6)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (4)
Low endotoxin level (4)
Select
E. coli
His
Less than 1.0 EU/µg protein (determined by LAL method).
22.6 kDa
10 µg/$376; 50 µg/$526
Select
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.9 kDa
10 µg/$288; 50 µg/$436
NOL3 / ARC Protein
Select
E. coli
His-SUMO
38.6 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
NOL3 / ARC Protein - 12.5% SDS-PAGE of human NOL3 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
49 kDa
10 µg/$479; 25 µg/$670
NOL3 / ARC Protein - Purified recombinant protein NOL3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$1,107
Select
293T Cells
Myc-DDK (Flag)
22.4 kDa
20 µg/$150
NOL3 / ARC Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
22.4 kDa
100 µg/$494
NOL3 / ARC Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
Select
E. coli
None
Less than 1.0 EU/µg protein (determined by LAL method).
22.63kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Select
E. coli
GST, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
48.92kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
Viewing 1-10 of 10 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).