Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Recognizes muramyl dipeptide (MDP) constituents of bacterial peptidoglycans and plays a key role in gastrointestinal immunity: upon stimulation, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling, leading to activate the transcription of hundreds of genes involved in immune response.
Gene Name: | nucleotide-binding oligomerization domain containing 2 |
Synonyms: | NOD2, BLAU, CARD15, ACUG, NOD-like receptor C2, NOD2B, NLRC2, IBD1, CLR16.3, PSORAS1 |
Target Sequences: | NM_022162 NP_071445.1 Q9HC29 |
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