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NNA1 / AGTPBP1

ATP/GTP binding protein 1

Metallocarboxypeptidase that mediates deglutamylation of target proteins. Catalyzes the deglutamylation of polyglutamate side chains generated by post-translational polyglutamylation in proteins such as tubulins. Also removes gene-encoded polyglutamates from the carboxy-terminus of target proteins such as MYLK. Acts as a long-chain deglutamylase and specifically shortens long polyglutamate chains, while it is not able to remove the branching point glutamate, a process catalyzed by AGBL5/CCP5.

Gene Name:	ATP/GTP binding protein 1
Synonyms:	AGTPBP1, ATP/GTP binding protein 1, ATP/GTP-binding protein 1, Carboxypeptidase-tubulin, Cytosolic carboxypeptidase 1, KIAA1035, NNA1, Tyrosine carboxypeptidase, Ccp1, Soluble carboxypeptidase, Tubulinyl-Tyr carboxypeptidase
Target Sequences:	NM_015239 NP_056054.2 Q9UPW5

Publications (1)

Bioinformatics Data Mining Approach Suggests Coexpression of AGTPBP1 with an ALS-linked Gene C9orf72. Kitano S, Kino Y, Yamamoto Y, Takitani M, Miyoshi J, Ishida T, Saito Y, Arima K, Satoh J. Journal of central nervous system disease. 2015 7:15-26. (WB; Human) [Full Text Article] [PubMed:26106267] [PMC:PMC4467204] Related Antibodies: LS-C175199.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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