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NLRP7 / NALP7
NLR family, pyrin domain containing 7
NLRP7 / NALP7 is a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Gene Name: | NLR family, pyrin domain containing 7 |
| Synonyms: | NLRP7, CLR19.4, NALP7, NOD12, PYPAF3, PAN7, HYDM |
| Target Sequences: | NP_631915.2 Q8WX94 |
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