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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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NKX3-1

NK3 homeobox 1

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Gene Name: NK3 homeobox 1
Synonyms: NKX3-1, BAPX2, NK homeobox, family 3, A, NK3 homeobox 1, NKX3, NKX3.1, Homeobox protein Nkx-3.1, NKX3A
Target Sequences: NM_006167 NP_006158.2 Q99801

Publications (4)

1
Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis. Kim MJ, Cardiff RD, Desai N, Banach-Petrosky WA, Parsons R, Shen MM, Abate-Shen C. Proceedings of the National Academy of Sciences of the United States of America. 2002 99:2884-9. [PubMed:11854455] [PMC:PMC122442]
2
A critical role for p27kip1 gene dosage in a mouse model of prostate carcinogenesis. Gao H, Ouyang X, Banach-Petrosky W, Borowsky AD, Lin Y, Kim M, Lee H, Shih WJ, Cardiff RD, Shen MM, Abate-Shen C. Proceedings of the National Academy of Sciences of the United States of America. 2004 101:17204-9. [PubMed:15569926] [PMC:PMC535400]
3
Nkx3.1 functions as para-transcription factor to regulate gene expression and cell proliferation in non-cell autonomous manner. Zhou J, Qin L, Tien JC, Gao L, Chen X, Wang F, Hsieh JT, Xu J. The Journal of biological chemistry. 2012 287:17248-56. (WB; Human, Rat) [PubMed:22465996] [PMC:PMC3366845]
4
NKX3.1 haploinsufficiency is prognostic for prostate cancer relapse following surgery or image-guided radiotherapy. Locke JA, Zafarana G, Ishkanian AS, Milosevic M, Thoms J, Have CL, Malloff CA, Lam WL, Squire JA, Pintilie M, Sykes J, Ramnarine VR, Meng A, Ahmed O, Jurisica I, van der Kwast T, Bristow RG. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Jan;18:308-16. [Full Text Article] [PubMed:22048240] Related Antibodies: LS-B3435.
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Viewing 1-25 of 111 items
NKX3-1 Antibody - Anti-NKX3-1 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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(1) Publication(s)
Mouse Monoclonal [clone 3-9] (IgG1) to Human NKX3-1
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $485.00
NKX3-1 Antibody - Anti-NKX3-1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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Mouse Monoclonal [clone 4H4] (IgG2b) to Human NKX3-1
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
NKX3-1 Antibody - Anti-NKX3-1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal to Human NKX3-1
Human
Flo, IHC, IHC-P, WB
Unconjugated
200µl   $425.00
NKX3-1 Antibody - Detection of NKX3.1 in mouse testis lysate using NKX3.1 Antibody. ECL detection 1 minute.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Mouse Monoclonal [clone 0361] to Human NKX3-1
Mouse, Rat
IHC, WB
Unconjugated
100µl   2.3mg/ml   $335.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer. (pH8.0) at 120C for 3 min. (1:200)
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Mouse Monoclonal [clone UMAB196] (IgG1) to Human NKX3-1
Human
IF, IHC, PMA, WB
Unconjugated
100µl   $395.00
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Mouse Monoclonal (IgG1) to Human NKX3-1
Human
ELISA, Flo, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
NKX3-1 Antibody - Nkx3.1 Antibody in Immunohistochemistry (IHC)
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Mouse Monoclonal [clone 4H4] (IgG2b) to Human NKX3-1
Human
Flo, IHC, WB
Unconjugated
100µl   $445.00
NKX3-1 Antibody - Anti-NKX3-1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Rabbit Polyclonal to Human NKX3-1
Human
IHC, IHC-P
Unconjugated
50µl   1mg/ml   $425.00
NKX3-1 Antibody - IHC of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI2D11] (IgG2b) to Human NKX3-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
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Mouse Monoclonal [clone OTI2D11] (IgG2b) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NKX3-1 Antibody - IHC of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI2A5] (IgG2a) to Human NKX3-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI2A5] (IgG2a) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NKX3-1 Antibody - IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI1C2] (IgG1) to Human NKX3-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI1C2] (IgG1) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NKX3-1 Antibody - IHC of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI6E7] (IgG1) to Human NKX3-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI6E7] (IgG1) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NKX3-1 Antibody - IHC of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
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Mouse Monoclonal [clone OTI9H7] (IgG1) to Human NKX3-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI9H7] (IgG1) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Mouse Monoclonal [clone 3 9] (IgG1) to Human NKX3-1
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µg   $395.00
NKX3-1 Antibody - Western blot of Nkx-3.1 antibody
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Rabbit Polyclonal (IgG) to Human NKX3-1
Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody.  Dilution: 1:150
Select
Mouse Monoclonal [clone OTI4B4] (IgG1) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NKX3-1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody.  Dilution: 1:150
Select
Mouse Monoclonal [clone OTI4H6] (IgG2a) to Human NKX3-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
NKX3-1 Antibody - Immunohistochemical staining of 3 cases of paraffin-embedded human endometrial carcinoma using anti-NKX3.1 clone UMAB195 mouse monoclonal antibody  at 1:100 with Polink2 Broad HRP DAB detection kit; heat-induced epitope retrieval with GBI ACCEL pH8.7 HIER buffer using pressure chamber for 3 minutes at 110C. No staining seen in the tumor cells but some cytoplasmic staining was visualized in the third case along with weak nuclear staining.
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Mouse Monoclonal [clone UMAB195] (IgG2a) to Human NKX3-1
Human
IHC, PMA
Unconjugated
100µl   $395.00
NKX3-1 Antibody
Select
Rabbit Polyclonal (IgG) to Human NKX3-1
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
NKX3-1 Antibody - IHC of paraffin-embedded Human prostate tissue using anti-NKX3-1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI2D2] (IgG1) to Human NKX3-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00

Viewing 1-25 of 111 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).