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In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression By similarity. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9.
Gene Name: | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein |
Synonyms: | NFATC2IP, ESC2, NIP45, NFATC2-interacting protein, RAD60 |
Target Sequences: | NM_032815 NP_116204.3 Q8NCF5 |
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