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NIN / Ninein

ninein (GSK3B interacting protein)

Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules.

Gene Name: ninein (GSK3B interacting protein)
Synonyms: NIN, GSK3B-interacting protein, HNinein, KIAA1565, Ninein, Ninein centrosomal protein, SCKL7
Target Sequences: NM_016350

Publications (5)

1
In-frame deletion in a novel centrosomal/ciliary protein CEP290/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse. Chang B, Khanna H, Hawes N, Jimeno D, He S, Lillo C, Parapuram SK, Cheng H, Scott A, Hurd RE, Sayer JA, Otto EA, Attanasio M, O'Toole JF, Jin G, Shou C, Hildebrandt F, Williams DS, Heckenlively JR, Swaroop A. Human molecular genetics. 2006 15:1847-57. [PubMed:16632484] [PMC:PMC1592550]
2
Ninein is expressed in the cytoplasm of angiogenic tip-cells and regulates tubular morphogenesis of endothelial cells. Matsumoto T, Schiller P, Dieterich LC, Bahram F, Iribe Y, Hellman U, Wikner C, Chan G, Claesson-Welsh L, Dimberg A. Arteriosclerosis, thrombosis, and vascular biology. 2008 28:2123-30. [PubMed:18772498]
3
The retinitis pigmentosa protein RP2 interacts with polycystin 2 and regulates cilia-mediated vertebrate development. Hurd T, Zhou W, Jenkins P, Liu CJ, Swaroop A, Khanna H, Martens J, Hildebrandt F, Margolis B. Human molecular genetics. 2010 19:4330-44. [PubMed:20729296] [PMC:PMC2957320]
4
Trichoplein controls microtubule anchoring at the centrosome by binding to Odf2 and ninein. Ibi M, Zou P, Inoko A, Shiromizu T, Matsuyama M, Hayashi Y, Enomoto M, Mori D, Hirotsune S, Kiyono T, Tsukita S, Goto H, Inagaki M. Journal of cell science. 2011 124:857-64. [PubMed:21325031]
5
Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein. Dauber A, Lafranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. The Journal of clinical endocrinology and metabolism. 2012 97:E2140-51. [PubMed:22933543] [PMC:PMC3485598]
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Proteins (5)
Over-Expression Lysate (2)
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NIN / Ninein (5)
No (5)
His-T7 (3)
Myc-DDK (Flag) (2)
Human (2)
Mouse (1)
Rat (1)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
NIN / Ninein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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NIN / Ninein Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110904
HEK 293 Cells
Myc-DDK (Flag)
248.1 kDa
100 µg/$710
NIN / Ninein Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human NIN / Ninein Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90355
293T Cells
Myc-DDK (Flag)
248.1 kDa
20 µg/$215
NIN / Ninein Protein - Recombinant Ninein By SDS-PAGE
Select
Human NIN / Ninein Protein (Recombinant His-T7) (aa1-153) - LS-G25033
E. coli
His-T7
21.3 kDa
10 µg/$271; 50 µg/$380; 100 µg/$607; 200 µg/$757; 1 mg/$1,810; 500 µg/$1,372; 5 mg/$2,768; 2 mg/$1,991
NIN / Ninein Protein - Recombinant Ninein By SDS-PAGE
Select
Mouse NIN / Ninein Protein (Recombinant His-T7) (aa1-153) - LS-G25034
E. coli
His-T7
21.1 kDa
10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119
NIN / Ninein Protein - Recombinant Ninein By SDS-PAGE
Select
Rat NIN / Ninein Protein (Recombinant His-T7) (aa1-153) - LS-G25035
E. coli
His-T7
21.1 kDa
10 µg/$276; 50 µg/$412; 100 µg/$657; 200 µg/$822; 1 mg/$1,905; 500 µg/$1,455; 5 mg/$2,871; 2 mg/$2,090
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