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NGN / Neogenin

neogenin 1

Multi-functional cell surface receptor regulating cell adhesion in many diverse developmental processes, including neural tube and mammary gland formation, myogenesis and angiogenesis. Receptor for members of the BMP, netrin, and repulsive guidance molecule (RGM) families. Netrin-Neogenin interactions result in a chemoattractive axon guidance response and cell-cell adhesion, the interaction between NEO1/Neogenin and RGMa and RGMb induces a chemorepulsive response.

Gene Name: neogenin 1
Synonyms: NEO1, Neogenin homolog 1, Neogenin (chicken) homolog 1, HsT17534, IGDCC2, Neogenin, Neogenin 1, NGN
Target Sequences: NM_002499 NP_002490.2 Q92859

Publications (1)

1
Rgma-Induced Neo1 Proteolysis Promotes Neural Tube Morphogenesis. Sharlene Brown, Pradeepa Jayachandran, Maraki Negesse, Valerie Olmo, Eudorah Vital, Rachel Brewster. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 Sep;39:7465-7484. [Full Text Article] [PubMed:31399534] [PMC:PMC6750935] Related Antibodies: LS-B13131.

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Proteins (4)
Over-Expression Lysate (2)
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NGN / Neogenin (4)
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6His, N-terminus (1)
Myc-DDK (Flag) (3)
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Rat (1)
293T Cells (1)
HEK 293 Cells (2)
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NGN / Neogenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
160.02 kDa
20 µg/$215
NGN / Neogenin Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Yeast
6His, N-terminus
33.0 kDa
100 µg/$570; 20 µg/$395; 1 mg/$1,973
NGN / Neogenin Protein - Purified recombinant protein NEO1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
156.4 kDa
20 µg/$1,107
NGN / Neogenin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
160.02 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).